نوع مقاله : مقاله پژوهشی Released under (CC BY-NC) license I Open Access I

نویسندگان

1 دانشیار دانشگاه مازندران،

2 دانشجوی دکتری فیزیولوژی ورزشی

چکیده

هدف: دی­پپتیدیل پپتیداز-4 (DPP-4) به عنوان پل ارتباطی بین چاقی و مقاومت به انسولین مطرح شده است. هدف از این پژوهش، بررسی تغییرات سطوح­سرمی DPP-4 و شاخص­مقاومت­به­انسولین (HOMA2-IR) پس از هشت­هفته تمرینات پیاده­روی تناوبی و تداومی در دختران چاق11-9ساله بود.
روش‌شناسی: 32 دختر چاق (با میانگین­سنی 75/0±62/9 سال و صدک شاخص­توده­بدنی40/1±38/97 درصد) به صورت داوطلبانه در پژوهش­حاضر شرکت­کردند و در گروه­های تمرین­تناوبی (12نفر)، تمرین­تداومی (11نفر) و کنترل (9نفر) قرارگرفتند. گروه­های تمرینی به مدت هشت­هفته، 3 جلسه در هفته (30 دقیقه پیاده­روی به ترتیب در گروه تداومی و تناوبی با شدت HRmax %60-75 و HRmax %70-85) پرداختند. پیاده­روی تناوبی شامل 2 دقیقه پیاده­روی و 1 دقیقه استراحت­فعال بود. پس از 10 ساعت ناشتایی، نمونه­گیری خون در قبل از شروع تمرینات و 72 ساعت پس از آخرین­جلسه­تمرینی انجام­گرفت. برای بررسی تغییرات درون­گروهی از آزمون­آماری t همبسته و برای بررسی تغییرات بین­گروهی، پس از محاسبه اختلاف بین پیش‌آزمون و پس‌آزمون از آنالیز واریانس یک‌طرفه استفاده شد.
یافته‌ها: هشت هفته تمرینات تداومی و تناوبی نسبت به گروه کنترل، تغییر معنی داری در سطوح DPP-4، انسولین، گلوکز و HOMA2-IR ایجاد نکرد. نسبت به گروه کنترل، تمرین تناوبی موجب بهبودی ­وزن، شاخص­توده­بدنی و صدک­شاخص­توده­بدنی (به­ترتیب 004/0p=، 019/0p= و 022/0p=) شد در حالی که فقط شاخص­توده­بدنی در گروه تمرین تداومی تمایل به کاهش داشت (077/0p=).
نتیجه‌گیری: به نظر می­رسد که بهبودی ترکیب بدن ناشی از پروتکل تمرینی مورد استفاده در این پژوهش، برای ایجاد تغییرات معنی دار HOMA2-IR و DPP-4 در دختران چاق نابالغ، کافی نبوده است.
 

کلیدواژه‌ها

عنوان مقاله [English]

The effect of eight weeks interval and continuous walking on serum levels of dipeptidyl peptidase-4 and insulin resistance index in obese girls aged 9-11 years old

نویسندگان [English]

  • R Fathi 1
  • M Baghersalimi 2
  • M Nazemi 2
  • A Khosravi 2

1 Associate Professor, University of Mazandaran

2 Phd student in Exercise Physiology

چکیده [English]

Aim: Dipeptidyl-peptidase-4 (DPP-4) has been proposed as a bridge between obesity and insulin resistance (IR). The aim of this study was to investigate the changes in serum levels of DPP-4 and HOMA2-IR after eight weeks of interval and continuous-walking in 9-11 year-old obese girls.
Method: thirty two-obese girls (age: 9.62±0.75 years and BMI-percentile: 97.38±1.40%) volunteered in this study and were assigned to interval (n=12), continuous (n=11) and control (n=9) groups. The training were performed for 8-weeks, 3-sessions per week (30-min walking in the continuous and interval groups with 60-75%HRmax and 70-85%HRmax, respectively). Interval-walking included 2-min of walking and 1-min of active rest. After 10-hours of fasting, blood sampling was performed before the beginning of training and 72-hours after the last session. The paired t-test was used to examine the within-group changes.
Results: Eight weeks of continuous and interval training did not significantly change the levels of DPP-4, insulin, glucose, and HOMA2-IR compared to the control group. Compared to the control group, the interval training resulted in improvement of the body weight, BMI, and BMI percentile (p=0.004, p=0.019, p=0.022), while the BMI only tended to decrease in the continuous training group (p=0.077).
Conclusion: It seems that the improvement of the body composition due to the protocol used in this study was not sufficient to make significant changes in the HOMA2-IR and DPP-4 in early-pubertal obese girls.
 

کلیدواژه‌ها [English]

  • Keywords: Obesity
  • Insulin resistance
  • Puberty
  • Dipeptidyl-peptidase-4
  • Walking
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