Metabolism and Exercise

The simultaneous effect of two months of combined training and taurine supplementation on BDNF, CRP and IL-6 indices in diabetic rats

Mehdi Pahlevani; Jabbar Bashiri; Roghayeh Pouzesh Jadidi; Rasoul Hashem Kandi Asadi; Masoomeh Dadkhah

Volume 11, Issue 2 , September 2022, , Pages 151-169

https://doi.org/10.22124/jme.2023.23972.257

Abstract

Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous ... Read More Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.

Effect of High-Intensity Interval Training and Curcumin Supplementation on Cardiac Tissue HSP60 and HSP20 Levels and Gene Expression levels of miR-21 and miR-30 in Rats Exposed to Arsenic

Aghil Mahdavi; Roghayeh Pouzesh Jadidi; Karim Azali Alamdari

Volume 12, Issue 1 , March 2022, , Pages 35-58

https://doi.org/10.22124/jme.2023.21057.223

Abstract

Introduction: The aim of this study was to evaluate the effects of high-intensity interval training (HIIT) and curcumin supplementation on cardiac heat shock proteins level and gene ... Read More

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Author = Roghayeh Pouzesh Jadidi

The simultaneous effect of two months of combined training and taurine supplementation on BDNF, CRP and IL-6 indices in diabetic rats

Abstract

Effect of High-Intensity Interval Training and Curcumin Supplementation on Cardiac Tissue HSP60 and HSP20 Levels and Gene Expression levels of miR-21 and miR-30 in Rats Exposed to Arsenic

Abstract