Metabolism and Exercise

The effect of aerobic training with resveratrol on the inflammatory and antioxidant indices of the hippocampus of rats with Alzheimer's disease

Ammar Rashet; Ahmad Abdi; alireza barari

Volume 14, Issue 2 , December 2024, , Pages 105-125

https://doi.org/10.22124/jme.2024.26320.342

Abstract

Introduction: To date, there is no cure or effective treatment for Alzheimer’s disease (AD). Promoting regular exercise and a diet containing polyphenols are effective non-pharmacological ... Read More Introduction: To date, there is no cure or effective treatment for Alzheimer’s disease (AD). Promoting regular exercise and a diet containing polyphenols are effective non-pharmacological approaches that prevent the progression of neurodegenerative diseases. In this study, inflammation and antioxidant markers were examined after eight weeks of exercise training (T), treatment with resveratrol (RSV), or a combination treatment in an Alzheimer's disease rat model. Materials & Methods: In this experimental study, 35 male Wistar rats (weight 223.17±9.07 grams and eight weeks old) were divided into 5 groups: Normal (NO), Alzheimer's (AD), Alzheimer's-Training (ADT), Alzheimer's-Resveratrol (ADRSV) and Alzheimer's-Training-Resveratrol (ADTRSV). Alzheimer's was induced using two microliters of amyloid-beta. The supplement groups received 20 mg of RSV (per kg of body weight) orally during the intervention period. Aerobic exercise program including running on treadmill with a speed of 6-18 meters per minute, was performed 5 days a week for eight weeks. Antioxidant indices were measured using fluorimetry and spectrophotometry, while gene expression was assessed by the RT-PCR method. Results: AD induction caused a significant decrease in antioxidant indices (GPx, SOD and CAT) and increased MDA, NF-κB, TNF-α and IL-1β (p=0.0001). Exercise and RSV decreased and increased the antioxidant indices and the expression of inflammatory factors (p<0.05). It was also observed a significant increase in Gpx and SOD levels in the ADTRSV compared to the ADT (p=0.043, p=0.041) and ADRSV (p=0.026, p=0.035, respectively). The expression of NF-κB and TNF-α was significantly decreased in ADTRSV compared to ADT (p=0.040 and p=0.041) and ADRSV (p=0.044 and p=0.034). Conclusion: Aerobic training and resveratrol may serve as an effective therapeutic strategy to prevent the progression of Alzheimer's disease by reducing inflammation and oxidative stress.

Psycho-physiological effects of high intensity interval training and vitamin E consumption in elderly trimethyltin-treated Alzheimer's rats

Omid Reza Salehi; Dariush Sheikholeslami-Vatani; Sayed Ali Hosseini

Volume 11, Issue 2 , September 2022, , Pages 57-76

https://doi.org/10.22124/jme.2023.23953.251

Abstract

Introduction: Aging is associated with neurodegenerative and psychological disorders. Considering the ambiguity in the interactive effect of exercise and antioxidants, the aim of this ... Read More

The effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in hippocampal tissue of male Wistar rats with Alzheimer's disease

A Fazeli Sani; hasan Matinhomaee; A Banaeifar

Volume 10, Issue 1 , May 2020

https://doi.org/10.22124/jme.2020.5775

Abstract

Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar ... Read More Aim: The aim of the present study was to investigate the effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in the hippocampal tissue of male Wistar rats with Alzheimer's disease.Methods: For this purpose, 21 male Wistar rats at 20 months of age were randomly divided into 3 groups: Alzheimer's disease (n = 7), Alzheimer's disease + aerobic exercise (n = 7) and control group (n = 7). Alzheimer's disease was induced by intrahippocampal injection of Aβ42 (1 microliter per side). Seven days after surgery, the exercise group performed 4 weeks of treadmill training (5 days per week at a speed of 10 to 15 m/min). Forty-eight hours after the last training session, the animals underwent behavioral tests. Twenty-four hours after the behavioral test, all rats were killed and hippocampal tissue was extracted. The mRNA expression of OPA1, Mfn2 and Drp1 genes was assayed using Real Time-PCR. One-way analysis of variance was used for statistical analysis.Ethical Considerations: All stages of the study were conducted according to the ethical guidelines and authorization of Research Deputy of Islamic Azad University, Central Tehran Branch No. IR.IAU.TMU.REC.1399.124.Results: The results showed that spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001) as well as the gene expression of OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) in animals with Alzheimer's disease decreased compared to the control group, while the gene expression of Drp1 increased (P ≤ 0.001). Aerobic exercise in patient animals improved spatial learning (P ≤ 0.001) and memory performance (P ≤ 0.001), increased hippocampal OPA1 (P ≤ 0.001) and Mfn2 (P ≤ 0.001) genes expression, and decreased Drp1 gene expression compared with Alzheimer's disease group (P ≤ 0.001).Conclusion: In general, it seems that aerobic exercise can improve spatial learning and memory performance in Alzheimer's disease by modulating abnormal mitochondrial dynamics.

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Keywords = Alzheimer's Disease

The effect of aerobic training with resveratrol on the inflammatory and antioxidant indices of the hippocampus of rats with Alzheimer's disease

Abstract

Psycho-physiological effects of high intensity interval training and vitamin E consumption in elderly trimethyltin-treated Alzheimer's rats

Abstract

The effect of 4 weeks of aerobic exercise on cognitive function and mitochondrial dynamics in hippocampal tissue of male Wistar rats with Alzheimer's disease

Abstract