University of Guilan Metabolism and Exercise 2322-2867 6 2 2016 07 10 The effect of acute Glutamine supplementation on inflammation caused by intense physical exercise in young male athletes The effect of acute Glutamine supplementation on inflammation caused by intense physical exercise in young male athletes 153 164 2319 10.22124/jme.2016.2319 FA J Mehrabani O Khoshkhoui Journal Article 2016 08 16 <strong>Aim: </strong>Systemic inflammation is one of the important consequences of the intensive physical exercises that can lead to decline in performance, same as leading to disorder of cell metabolism and inflammation acute phase responses. probably immune booster supplements can be effective in improving these functions. The present study assessing the effects of a treadmill exhaustive exercise after taking Glutamine on level of glucose, insulin, hs-CRP  WBC, lactate and fibrinogen among 19 young athletic men <strong>Method:</strong> The participants were selected randomly and divided into two groups of Glutamine (n=9, age: 21.1±0.8yr; weight: 68.9±6.2kg) and placebo (n= 10, age: 20.9±0.6yr; weight: 66.9±6.8kg). Glutamine group received 16gr. Glutamine mixed in 50gr. sucrose (sugar), 1.5gr. lemon juice and  300ml water. The placebo group, on the other hand, received 300ml solution of 5% sucrose (i.e. 300ml and 5% sucrose (sugar) and 0.15% lemon juice. After 15min of rest, the participants took glutamine and placebo using double blind method and engaged in an exhaustive Bruce protocol after 1hr of rest. <strong>Results</strong>: The results showed that blood hs-CRP level in the Glutamine group was not changed significantly comparing with that of placebo group immediately after exercise. Although, blood level of glucose, insulin and fibrinogen showed significant changes immediately after exercise between the Glutamine and placebo, and an increase immediately after exercise compared to pre-exercise (p<0.05). <strong>Conclusion:</strong> Apparently, exercise and taking Glutamine influences on hs-CRP level; although, did not stop increase in glucose, insulin and fibrinogen after exhaustive exercise. It seems taking supplementary Glutamine, probably, can decrease blood level of CRP as a major acute phase response after an intense exercise.   <strong>Aim: </strong>Systemic inflammation is one of the important consequences of the intensive physical exercises that can lead to decline in performance, same as leading to disorder of cell metabolism and inflammation acute phase responses. probably immune booster supplements can be effective in improving these functions. The present study assessing the effects of a treadmill exhaustive exercise after taking Glutamine on level of glucose, insulin, hs-CRP  WBC, lactate and fibrinogen among 19 young athletic men <strong>Method:</strong> The participants were selected randomly and divided into two groups of Glutamine (n=9, age: 21.1±0.8yr; weight: 68.9±6.2kg) and placebo (n= 10, age: 20.9±0.6yr; weight: 66.9±6.8kg). Glutamine group received 16gr. Glutamine mixed in 50gr. sucrose (sugar), 1.5gr. lemon juice and  300ml water. The placebo group, on the other hand, received 300ml solution of 5% sucrose (i.e. 300ml and 5% sucrose (sugar) and 0.15% lemon juice. After 15min of rest, the participants took glutamine and placebo using double blind method and engaged in an exhaustive Bruce protocol after 1hr of rest. <strong>Results</strong>: The results showed that blood hs-CRP level in the Glutamine group was not changed significantly comparing with that of placebo group immediately after exercise. Although, blood level of glucose, insulin and fibrinogen showed significant changes immediately after exercise between the Glutamine and placebo, and an increase immediately after exercise compared to pre-exercise (p<0.05). <strong>Conclusion:</strong> Apparently, exercise and taking Glutamine influences on hs-CRP level; although, did not stop increase in glucose, insulin and fibrinogen after exhaustive exercise. It seems taking supplementary Glutamine, probably, can decrease blood level of CRP as a major acute phase response after an intense exercise.   https://jme.guilan.ac.ir/article_2319_4f996a516b427c9ab8044d7628b1def0.pdf