University of Guilan Metabolism and Exercise 2322-2867 12 1 2022 09 23 The effect of combined exercise training on cardiovascular inflammatory markers, lipid profile and blood pressure in hypertensive men The effect of combined exercise training on cardiovascular inflammatory markers, lipid profile and blood pressure in hypertensive men 1 16 5913 10.22124/jme.2021.15316.174 FA Navid Nateghi University of Guilan, University Campuse 2 Arsalan Damirchi Javad Mehrabani Department of Exercise Physiology, University of Guilan, Rasht, Guilan, Iran Razhan Piran Shahid Rajaei Hospital Journal Article 2022 04 28 Hypertension similar to dyslipidemia is most important cardiovascular diseases that exercise training can have a preventive and therapeutic effect on them. The effect of combined exercise training as an effective method is one of the new ways to combat hypertension and cardiovascular health. The purpose of this study was to investigate the effect of combined exercises training on cardiovascular inflammatory markers and blood pressure in hypertensive men.<br />In this study that designed with pre-post tests with control group, 9 men (47.33±4.5 years; body mass index 33.18±5.27 kg/m2) as combined training group [COT] and 9 as control group [CON] (48.44±3.20 years; body mass index 30.51±5.35 kg/m2) were randomly selected from volunteers. Combined training (aerobic and resistance) that performed in 16 weeks consisted of 4 sessions per week (2 sessions of aerobic and dynamic resistance training, respectively). Aerobic training with 40-65% maximal oxygen uptake (70-80 minutes) and dynamic resistance training with 55% maximum repetition (70-80 minutes) were performed. Results of ANCOVA test showed that systolic and diastolic blood pressure, galactin-3 and endothelin-1 plasma levels were significantly decreased in the post exercise training group as well as in the control group (p<0.05). In lipid profile, we observed significant decrease in total cholesterol (TChol) in combined exercise training group (p<0.05). It can be concluded that, the results showed that the combination of aerobic and resistance training, in addition to lowering blood pressure and improvement of dyslipidemia in men with hypertension, led to a decrease in biomarkers affecting vascular inflammation and heart failure. Hypertension similar to dyslipidemia is most important cardiovascular diseases that exercise training can have a preventive and therapeutic effect on them. The effect of combined exercise training as an effective method is one of the new ways to combat hypertension and cardiovascular health. The purpose of this study was to investigate the effect of combined exercises training on cardiovascular inflammatory markers and blood pressure in hypertensive men.<br />In this study that designed with pre-post tests with control group, 9 men (47.33±4.5 years; body mass index 33.18±5.27 kg/m2) as combined training group [COT] and 9 as control group [CON] (48.44±3.20 years; body mass index 30.51±5.35 kg/m2) were randomly selected from volunteers. Combined training (aerobic and resistance) that performed in 16 weeks consisted of 4 sessions per week (2 sessions of aerobic and dynamic resistance training, respectively). Aerobic training with 40-65% maximal oxygen uptake (70-80 minutes) and dynamic resistance training with 55% maximum repetition (70-80 minutes) were performed. Results of ANCOVA test showed that systolic and diastolic blood pressure, galactin-3 and endothelin-1 plasma levels were significantly decreased in the post exercise training group as well as in the control group (p<0.05). In lipid profile, we observed significant decrease in total cholesterol (TChol) in combined exercise training group (p<0.05). It can be concluded that, the results showed that the combination of aerobic and resistance training, in addition to lowering blood pressure and improvement of dyslipidemia in men with hypertension, led to a decrease in biomarkers affecting vascular inflammation and heart failure. https://jme.guilan.ac.ir/article_5913_e2f2592604a14a71fd96ba37cd678f20.pdf