University of Guilan Metabolism and Exercise 2322-2867 11 2 2021 09 23 Six weeks of continuous aerobic training increases the neuronal density in the CA1 area of ​​the hippocampus and improves memory performance in aged AD model rats Six weeks of continuous aerobic training increases the neuronal density in the CA1 area of ​​the hippocampus and improves memory performance in aged AD model rats 113 128 6318 10.22124/jme.2023.24064.280 FA Aylar Fathi Department of Sport Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, Iran Simin Namvar Department of biology, Faculty of Basic Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran. Journal Article 2023 03 09 Alzheimer's disease is a neurodegenerative disease. In this disease, the accumulation of beta-amyloid plaques in the brain causes a decrease in nerve density and the volume of the hippocampus. Studying the types of sports activities and finding the best type is considered as a way to control Alzheimer's. The aim of the current research was to study the effect of six weeks of continuous aerobic training on the neuronal density of the hippocampus CA1 region and memory performance.<br />The current research was carried out experimentally. The statistical population was male Wistar rats with a weight range of 300 to 350 grams. For this purpose, 40 11-month-old male rats were prepared and randomly divided into four groups of 10 including the training patient group, control patient group, healthy training group and healthy control group. The rats performed the relevant exercises for six weeks by repeating five sessions per week. 48 hours after the last session, brain tissue was removed and data were collected. Neuronal density was measured by histological method and memory performance by novel object recognition test. The results were extracted using two-way variance analysis at a significance level of p≥0.05.<br />Neuron density in the hippocampus in the training patient group increased significantly compared to the control patient group. Also, improvement of memory performance was observed in the training patient group compared to the control patient group (p=0.004). Performing continuous aerobic exercises for six weeks increases the neuronal density in the hippocampus and improves memory function in Alzheimer's disease. Alzheimer's disease is a neurodegenerative disease. In this disease, the accumulation of beta-amyloid plaques in the brain causes a decrease in nerve density and the volume of the hippocampus. Studying the types of sports activities and finding the best type is considered as a way to control Alzheimer's. The aim of the current research was to study the effect of six weeks of continuous aerobic training on the neuronal density of the hippocampus CA1 region and memory performance.<br />The current research was carried out experimentally. The statistical population was male Wistar rats with a weight range of 300 to 350 grams. For this purpose, 40 11-month-old male rats were prepared and randomly divided into four groups of 10 including the training patient group, control patient group, healthy training group and healthy control group. The rats performed the relevant exercises for six weeks by repeating five sessions per week. 48 hours after the last session, brain tissue was removed and data were collected. Neuronal density was measured by histological method and memory performance by novel object recognition test. The results were extracted using two-way variance analysis at a significance level of p≥0.05.<br />Neuron density in the hippocampus in the training patient group increased significantly compared to the control patient group. Also, improvement of memory performance was observed in the training patient group compared to the control patient group (p=0.004). Performing continuous aerobic exercises for six weeks increases the neuronal density in the hippocampus and improves memory function in Alzheimer's disease. https://jme.guilan.ac.ir/article_6318_f84d1fad03c319fdfce5719696b8cd8c.pdf