University of Guilan Metabolism and Exercise 2322-2867 11 2 2021 09 23 The effect of a period of intermittent training on gene expression of TNF-α, CRP and IL-10 factors in the heart tissue of diabetic male rats The effect of a period of intermittent training on gene expression of TNF-α, CRP and IL-10 factors in the heart tissue of diabetic male rats 183 201 6357 10.22124/jme.2023.23996.268 FA Hamid Malekshahiniya PhD in Cardiac Exercise Physiology, Faculty of Sports Sciences, Kharazmi University, Tehran, Iran 0000-0001-6364-1751 Roohollah Mohammadi Mirzaei Assistant Professor, Department of Sports Sciences, Farhangian University, Shahid Chamran Campus, Tehran, Iran 0000-0001-6364-1751 Halimeh Vahdatpoor Phd Exercise Physiology, Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran 0000-0001-6364-1751 M Azarniveh Assistant Professor, Department of Sports Physiology, Faculty of Literature and Human Sciences, Zabol, Zabol, Iran. Journal Article 2023 03 01 Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05. Results: The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01). Conclusion: The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients. Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05. Results: The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01). Conclusion: The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients. https://jme.guilan.ac.ir/article_6357_4f7d6373a0282a71023f463b87f08717.pdf