University of Guilan Metabolism and Exercise 2322-2867 1 1 2011 04 01 Monitoring of time course response in GH, Insulin, IGF-1, IGFBP-1 and IGFBP-3 after heavy resistance exercise in trained and non-trained men Monitoring of time course response in GH, Insulin, IGF-1, IGFBP-1 and IGFBP-3 after heavy resistance exercise in trained and non-trained men 61 78 661 FA Hamid Rajabi Ehsan Soleymani Far Shirin Hasani Ranjbar Ramin Heshmat Journal Article 1970 01 01 AbstractAim: This study aimed to investigate the effects of intense resistance exercise on IGF-1 system and monitoring time course of changes in its components.Method: Nineteen healthy physical education students as trained group (age 22.21±1.44 years, height 178.41±6.39 cm, weight 73.47±7.86 kg) and fifteen healthy nonphysical education students as untrained group (age 23.07±1.91 years, height 174.02±5.08 cm, weight 70.47±10.13 kg) volunteered to participate in this study and each group were randomly divided into two experimental and control groups. Experimental groups performed one session of resistance exercise with 70-80% 1RM. Blood sampling was done 4 times, 2-hours after breakfast (Pre-test), immediately (T2), 4- (T3) and 7-hours after the exercise (T4). Blood samples were analyzed by RIA method. Two-way repeated measure (ANOVA), Friedman and Kruskal-Walis tests were used to analyze data.Results: One session of resistance exercise was associated with a significant increase in GH at T2 (P<0.05), and a significant decrease in both insulin at all the post-exercise time points and IGFBP3 at T4 (P<0.05) in trained group. In untrained group no statistically significant changes was observed in any variables. However, variables changed similarly in both experimental groups. IGFBP1 did not change significantly at length of time.Conclusion: In conclusion, the findings indicate that heavy resistance exercise can lead to changes in IGF-1 system components. The amount of change depends on subjects’ fitness and variables of exercise.Key words: GH, Insulin, IGF-1, IGFBP1, IGFBP3, Heavy resistance exercise AbstractAim: This study aimed to investigate the effects of intense resistance exercise on IGF-1 system and monitoring time course of changes in its components.Method: Nineteen healthy physical education students as trained group (age 22.21±1.44 years, height 178.41±6.39 cm, weight 73.47±7.86 kg) and fifteen healthy nonphysical education students as untrained group (age 23.07±1.91 years, height 174.02±5.08 cm, weight 70.47±10.13 kg) volunteered to participate in this study and each group were randomly divided into two experimental and control groups. Experimental groups performed one session of resistance exercise with 70-80% 1RM. Blood sampling was done 4 times, 2-hours after breakfast (Pre-test), immediately (T2), 4- (T3) and 7-hours after the exercise (T4). Blood samples were analyzed by RIA method. Two-way repeated measure (ANOVA), Friedman and Kruskal-Walis tests were used to analyze data.Results: One session of resistance exercise was associated with a significant increase in GH at T2 (P<0.05), and a significant decrease in both insulin at all the post-exercise time points and IGFBP3 at T4 (P<0.05) in trained group. In untrained group no statistically significant changes was observed in any variables. However, variables changed similarly in both experimental groups. IGFBP1 did not change significantly at length of time.Conclusion: In conclusion, the findings indicate that heavy resistance exercise can lead to changes in IGF-1 system components. The amount of change depends on subjects’ fitness and variables of exercise.Key words: GH, Insulin, IGF-1, IGFBP1, IGFBP3, Heavy resistance exercise https://jme.guilan.ac.ir/article_661_4edc16b28afb9136fddd5e268deba45b.pdf