University of Guilan Metabolism and Exercise 2322-2867 15 1 2025 07 23 The effect of 12 weeks of aerobic and resistance training on leptin and resistin levels in women with gestational diabetes The effect of 12 weeks of aerobic and resistance training on leptin and resistin levels in women with gestational diabetes 49 67 8583 10.22124/jme.2025.29198.383 FA Azam Mollanovruzi Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Iran Mitra Khademosharie Department of Sport Sciences, Faculty of Humanities, Kosar University of Bojnord, Iran Marziye Azarniveh Sports Science Department, Faculty of Literature and Human Sciences, Zabol University, Zabol, Iran Journal Article 2024 12 08 Background and Objective: The prevalence of gestational diabetes mellitus (GDM) has increased in recent decades. Two important hormones in this field, resistin and leptin, play a fundamental role in regulating metabolism and insulin sensitivity. Therefore, the aim of the present study was to investigate the effect of 12 weeks of aerobic and resistance training on the levels of these adipokines in women with gestational diabetes.<br />Research Methods: For the study, 28 pregnant women aged 25 to 35 years with gestational diabetes and a gestational age of 13 to 14 weeks were voluntarily selected and randomly divided into two experimental groups (n = 14) and control (n = 14). The combined exercise program (aerobic and resistance) consisted of three training sessions per week for 12 weeks. Necessary measurements and blood tests were performed 24 hours before the start of the exercises and 24 hours after the last exercise session. Repeated Measure ANOVA was used to analyze the data. In the present study, the significance level was considered to be p≤0.05 and the data were analyzed using SPSS version 23 software.<br />Results: 12 weeks of combined exercises significantly reduced resistin (P=0.001), leptin (P=0.001) and serum glucose (P=0.001) .<br />Conclusion: It can be said that as a result of exercise training, especially combined training, there was an improvement in factors affecting gestational diabetes, and the results of the present study showed that pregnant diabetic women can benefit from many benefits with exercise training, including a reduction in adipokines secreted from adipose tissue. Background and Objective: The prevalence of gestational diabetes mellitus (GDM) has increased in recent decades. Two important hormones in this field, resistin and leptin, play a fundamental role in regulating metabolism and insulin sensitivity. Therefore, the aim of the present study was to investigate the effect of 12 weeks of aerobic and resistance training on the levels of these adipokines in women with gestational diabetes.<br />Research Methods: For the study, 28 pregnant women aged 25 to 35 years with gestational diabetes and a gestational age of 13 to 14 weeks were voluntarily selected and randomly divided into two experimental groups (n = 14) and control (n = 14). The combined exercise program (aerobic and resistance) consisted of three training sessions per week for 12 weeks. Necessary measurements and blood tests were performed 24 hours before the start of the exercises and 24 hours after the last exercise session. Repeated Measure ANOVA was used to analyze the data. In the present study, the significance level was considered to be p≤0.05 and the data were analyzed using SPSS version 23 software.<br />Results: 12 weeks of combined exercises significantly reduced resistin (P=0.001), leptin (P=0.001) and serum glucose (P=0.001) .<br />Conclusion: It can be said that as a result of exercise training, especially combined training, there was an improvement in factors affecting gestational diabetes, and the results of the present study showed that pregnant diabetic women can benefit from many benefits with exercise training, including a reduction in adipokines secreted from adipose tissue. https://jme.guilan.ac.ir/article_8583_9a0b4102fef2223401524a7b6802657f.pdf