University of GuilanMetabolism and Exercise2322-286712220220923The effect of endurance training and chlorogenic acid consumption on oxidative stress markers in diabetic micesThe effect of endurance training and chlorogenic acid consumption on oxidative stress markers in diabetic mices115631310.22124/jme.2023.23408.236FASaharGhasemi PourDepartment of sport sciences, University of Isfahan, Isfahan, IranSayyed MohammadMarandiDepartment of sport sciences, University of Isfahan, Isfahan, IranJournal Article20221208Oxidative stress is involved in occurrence and side effects of many diseases .Considering the high prevalence of diabetes in the society and the economic and health consequences caused by it, the present study tries to evaluate the effect of endurance exercise and chlorogenic acid on some pressure indicators.35 4 weeks male C57BL6 mice were randomly assigned to two groups of high-fat diet to induce pre-diabetes and normal diet. After induction of prediabetes,after 12 weeks of high fat diet consumption the samples of this group were divided into groups without intervention, chlorogenic acid consumption, endurance training, endurance training and chlorogenic acid (n=7). The training protocol was performed incrementally . Chlorogenic acid at the rate of 110 mg per kilogram of mouse weight was given to the groups . 24 hours after the last training session and consumption of chlorogenic acid, tissue removal was done from the quadriceps skeletal muscle and after weighing, it was taken to the laboratory to measure GPX, NO, TAC and MDA. One-way ANOVA test at 0.05 level was used to analyze the data. Findings: Endurance training decreased GPX, NO, TAC, and MDA. Chlorogenic acid decreased GPX, NO, and increased TAC and MDA, and their simultaneous intervention increased GPX, TAC, and MDA and decreased NO.According to the findings of this research, it seems that endurance exercise and chlorogenic acid consumption can be used as a non-pharmacological intervention to prevent oxidative stress in the body and its complications. It can also play a preventive role in diabetic patients.Oxidative stress is involved in occurrence and side effects of many diseases .Considering the high prevalence of diabetes in the society and the economic and health consequences caused by it, the present study tries to evaluate the effect of endurance exercise and chlorogenic acid on some pressure indicators.35 4 weeks male C57BL6 mice were randomly assigned to two groups of high-fat diet to induce pre-diabetes and normal diet. After induction of prediabetes,after 12 weeks of high fat diet consumption the samples of this group were divided into groups without intervention, chlorogenic acid consumption, endurance training, endurance training and chlorogenic acid (n=7). The training protocol was performed incrementally . Chlorogenic acid at the rate of 110 mg per kilogram of mouse weight was given to the groups . 24 hours after the last training session and consumption of chlorogenic acid, tissue removal was done from the quadriceps skeletal muscle and after weighing, it was taken to the laboratory to measure GPX, NO, TAC and MDA. One-way ANOVA test at 0.05 level was used to analyze the data. Findings: Endurance training decreased GPX, NO, TAC, and MDA. Chlorogenic acid decreased GPX, NO, and increased TAC and MDA, and their simultaneous intervention increased GPX, TAC, and MDA and decreased NO.According to the findings of this research, it seems that endurance exercise and chlorogenic acid consumption can be used as a non-pharmacological intervention to prevent oxidative stress in the body and its complications. It can also play a preventive role in diabetic patients.https://jme.guilan.ac.ir/article_6313_e381212e59a4a12e24b5770f1007d2d1.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923Effects of aerobic training and curcumin supplementation on some mitophagy indices induced by renal ischemia/reperfusion of male ratsEffects of aerobic training and curcumin supplementation on some mitophagy indices induced by renal ischemia/reperfusion of male rats1635633010.22124/jme.2023.23952.250FAAmirDadashzadehDepartment of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, IranRoghayehPouzesh Jadidi: Assistant Prof., Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, IranOmidAzin FamDepartment of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran0000-0001-6126-7954JabraeelPouzesh JadidiDepartment of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, IranJournal Article20230226Aim: Was to investigate the effects of eight weeks aerobic training and curcumin supplementation on some mitophagy indices induced by ischemia/reperfusion of male rats. Methods: Fifty eight (age: 12 weeks, weight: 315.23 ± 28.57 gr) male rats were randomized into five groups including on Healthy control, Ischemic cotrol, Curcumin, Training, Training+Curcumin(Concomitant). Aerobic training program were conducted for eight weeks (5 d/w) starting with running at a speed of 10 m/min, 5% incline for 10 min per day. The running speed and time were gradually increased up to 15-20 m/min per day. In the last two sessions, the intensity of aerobic training reached 25 m/min for 30 min per day with 2 min recovery period at 10 m/min. curcumin (200 mg/bw.day) were consumed through oral gavage for six weeks. The gene expression levels of miR-1 and miR-133 were evaluated using Real-Time PCR method and the data were analyzed using one-way analysis of variance and Tukey post hoc test at the significance level of p <0.05. Results: In all four intervention groups, including ischemia control, exercise, curcumin and combination, the expression of HIF-1α and BNIP3 in renal tissue increased significantly (p=0.001 in all groups) compared to the control group. However, the expression of HIF-1α and BNIP3 genes in renal tissue after exercise caused a significant decrease and increase (p=0.007 and p=0.01, respectively) compared to the healthy control and ischemic control groups. Also, curcumin and Concomitant were associated with an increase in HIF-1α and BNIP3 gene expression in renal tissueAim: Was to investigate the effects of eight weeks aerobic training and curcumin supplementation on some mitophagy indices induced by ischemia/reperfusion of male rats. Methods: Fifty eight (age: 12 weeks, weight: 315.23 ± 28.57 gr) male rats were randomized into five groups including on Healthy control, Ischemic cotrol, Curcumin, Training, Training+Curcumin(Concomitant). Aerobic training program were conducted for eight weeks (5 d/w) starting with running at a speed of 10 m/min, 5% incline for 10 min per day. The running speed and time were gradually increased up to 15-20 m/min per day. In the last two sessions, the intensity of aerobic training reached 25 m/min for 30 min per day with 2 min recovery period at 10 m/min. curcumin (200 mg/bw.day) were consumed through oral gavage for six weeks. The gene expression levels of miR-1 and miR-133 were evaluated using Real-Time PCR method and the data were analyzed using one-way analysis of variance and Tukey post hoc test at the significance level of p <0.05. Results: In all four intervention groups, including ischemia control, exercise, curcumin and combination, the expression of HIF-1α and BNIP3 in renal tissue increased significantly (p=0.001 in all groups) compared to the control group. However, the expression of HIF-1α and BNIP3 genes in renal tissue after exercise caused a significant decrease and increase (p=0.007 and p=0.01, respectively) compared to the healthy control and ischemic control groups. Also, curcumin and Concomitant were associated with an increase in HIF-1α and BNIP3 gene expression in renal tissuehttps://jme.guilan.ac.ir/article_6330_ac53a55872abc866f01a972431247128.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923The Effect of Interval Resistance Training with different intensity on Interleukin-6, Tumor Necrosis Factor –α and NRG-4 in Obese MenThe Effect of Interval Resistance Training with different intensity on Interleukin-6, Tumor Necrosis Factor –α and NRG-4 in Obese Men3655636110.22124/jme.2023.24017.272FAEnsiyehYazdkhastiDepartment of physical education and sport sciences, Faculty of education and psycology, University of mohagheghe ardabili, Ardabil, Iran.FarnazSeifi-SkishahrDepartment of physical education and sport sciences, Faculty of education and psycology, University of mohagheghe ardabili, Ardabil, Iran.RezaFarzizadehDepartment of physical education and sport sciences, Faculty of education and psycology, University of mohagheghe ardabili, Ardabil, Iran.Journal Article20230303Aims: The purpose of this study was to investigate the effect of Interval resistance training with different intensities on the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and neuroglin-4 (NRG-4) in obese men.<br /><br />Methods: In this semi- experimental research, 44 obese men aged 20-30 years old in Tabriz city were selected and divided into 4 control groups, low intensity Interval resistance training with low intensity, medium intensity and high intensity. In the continuation, the subjects of the resistance training group performed their training program for 12 weeks, three sessions a week with 3 different intensities (40% 1RM with 20 repetitions, 60% 1RM with 12 repetitions and 80% 1RM with 20 repetitions) and 48 hours before the first training session and 48 hours after the last resistance training session, the subjects' personal characteristics and serum levels of IL-6, TNF-α and NRG-4 were measured by ELISA. <br /><br />Results: The research findings showed that 12 weeks Interval resistance training decreased serum levels of IL-6 in group with high intensity (P=0.01) and increased serum levels of NRG-4 in exercise groups with different intensities(P=0.001) in obese men, but it had no significant effect on TNF-α levels (P=0.05). The dcrease in IL-6 and increase in neuroglin-4 levels in the high intensity Interval resistance training group (P=0.02) was the most compared to other groups (P=0.02 and P=0.001; respectively). <br /><br />Conclusion: It seems that Interval resistance training with different intensities can improve inflammatory indices and neuroglin-4 in obese people, and this improvement was more prominent in high-intensity resistance training.Aims: The purpose of this study was to investigate the effect of Interval resistance training with different intensities on the levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and neuroglin-4 (NRG-4) in obese men.<br /><br />Methods: In this semi- experimental research, 44 obese men aged 20-30 years old in Tabriz city were selected and divided into 4 control groups, low intensity Interval resistance training with low intensity, medium intensity and high intensity. In the continuation, the subjects of the resistance training group performed their training program for 12 weeks, three sessions a week with 3 different intensities (40% 1RM with 20 repetitions, 60% 1RM with 12 repetitions and 80% 1RM with 20 repetitions) and 48 hours before the first training session and 48 hours after the last resistance training session, the subjects' personal characteristics and serum levels of IL-6, TNF-α and NRG-4 were measured by ELISA. <br /><br />Results: The research findings showed that 12 weeks Interval resistance training decreased serum levels of IL-6 in group with high intensity (P=0.01) and increased serum levels of NRG-4 in exercise groups with different intensities(P=0.001) in obese men, but it had no significant effect on TNF-α levels (P=0.05). The dcrease in IL-6 and increase in neuroglin-4 levels in the high intensity Interval resistance training group (P=0.02) was the most compared to other groups (P=0.02 and P=0.001; respectively). <br /><br />Conclusion: It seems that Interval resistance training with different intensities can improve inflammatory indices and neuroglin-4 in obese people, and this improvement was more prominent in high-intensity resistance training.https://jme.guilan.ac.ir/article_6361_f7d71c7a6d1f0d1efeb8dcaa1066c047.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923The effect of two weeks of intermittent training with and without blood flow restriction on some anabolic indices in amateur adolescent football playersThe effect of two weeks of intermittent training with and without blood flow restriction on some anabolic indices in amateur adolescent football players5669636610.22124/jme.2023.24104.283FAJavadVakiliSports Physiology, Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran0000-0002-7100-8961SaeedNikookheslatDepartment of exercise physiology, Faculty of physical education and sport sciences, University of Tabriz, Tabriz, IranMohammadTanhaeiDepartment of exercise physiology, Faculty of physical education and sport sciences, University of Tabriz, Tabriz, IranMaryamAkbari, physical education office, Tabriz university of medicine sciences. Tabriz, IranJournal Article20230313Objective: Training with blood flow restriction likely have a profound effect on growth related hormonal indices. The purpose of this study was to determine the effect of two weeks intermittent training with and without blood flow restriction on serum levels of growth hormone, IGF-1 and Lactate in amateur adolescent football players. <br /><br />Methodology: Therefor 24 amateur adolescent football players with age of 17/79±0/79 years-old, height of 175/41 ± 3/37 cm and weight of 69/12±4/49 kg were voluntarily selected and divided based on VO2max into two groups of control and experimental groups. The training protocol was performed in treadmill with intensity of 60-75% MHR, four sessions per week, in 400 meters, three sets in first week and four sets in second week. Recovery intervals was 60-80 seconds between exercise intervals. The thigh cuff pressure was set between 140 and 180 mmHg. Blood samples were gathered in two phases before of training protocol and 48h after last session of training for analyses of serum GH, IGF-1 levels and lactate immediately after the RAST anaerobic test. Independent and dependent T-test was used for data analyzing and significant level was set at p<0/05. <br /><br />Results: There was a significant increase in serum GH (p=0/016) and lactate (p=0/000) in BFR group. But there weren’t any difference between two group in serum IGF-1 after BFR and nonBFR training (P >0/05).<br /><br />Conclusion: it is concluded that intermittent trainings with BFR probably be more effective in enhancing adolescent’s growth indicators than intermittent training.Objective: Training with blood flow restriction likely have a profound effect on growth related hormonal indices. The purpose of this study was to determine the effect of two weeks intermittent training with and without blood flow restriction on serum levels of growth hormone, IGF-1 and Lactate in amateur adolescent football players. <br /><br />Methodology: Therefor 24 amateur adolescent football players with age of 17/79±0/79 years-old, height of 175/41 ± 3/37 cm and weight of 69/12±4/49 kg were voluntarily selected and divided based on VO2max into two groups of control and experimental groups. The training protocol was performed in treadmill with intensity of 60-75% MHR, four sessions per week, in 400 meters, three sets in first week and four sets in second week. Recovery intervals was 60-80 seconds between exercise intervals. The thigh cuff pressure was set between 140 and 180 mmHg. Blood samples were gathered in two phases before of training protocol and 48h after last session of training for analyses of serum GH, IGF-1 levels and lactate immediately after the RAST anaerobic test. Independent and dependent T-test was used for data analyzing and significant level was set at p<0/05. <br /><br />Results: There was a significant increase in serum GH (p=0/016) and lactate (p=0/000) in BFR group. But there weren’t any difference between two group in serum IGF-1 after BFR and nonBFR training (P >0/05).<br /><br />Conclusion: it is concluded that intermittent trainings with BFR probably be more effective in enhancing adolescent’s growth indicators than intermittent training.https://jme.guilan.ac.ir/article_6366_149f63b6b7c83c1fcdb989b202048ca4.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923The effect of 6 weeks of CXWORX training with nettle supplementation on lipid profile, C-reactive protein and some body composition indices in overweight and obese womenThe effect of 6 weeks of CXWORX training with nettle supplementation on lipid profile, C-reactive protein and some body composition indices in overweight and obese women7089636910.22124/jme.2023.23978.261FAMehdiMogharnasiProfessor of Exercise
Physiology, Faculty of Sports
Sciences, University of Birjand,FaezehMemarzadehDepartment of Sport Sciences, Faculty of Sport Sciences, University of Birjand, Birjand, IranAliSeghatoleslamiDepartment of Sport Sciences, Faculty of Sport Sciences, Birjand, IranJournal Article20230228Background and Aim: The aim of this study was to investigate the effect of 6 weeks of CXWORX training along with nettle supplement consumption on lipid profile, C-reactive protein and some body composition indicators of overweight and obese women. Methods: The current research was semi-experimental with a pre-test and post-test design. For this purpose, 48 overweight and obese women with an age range of 20-40 years and a body mass index (BMI) between 25-34 kg/m2 were purposefully selected and divided into 4 groups: exercise + nettle, exercise + placebo, nettle and Placebo was divided. All measurements were done one stage before the start of the course and another stage after the course was finished. After collecting the data, the data were analyzed with SPSS software, and Shapiro-Wilk, T-correlated tests and one-way analysis of variance were used at a significance level of p<0.05. Results: The results showed that after 6 weeks of intervention, the levels of triglycerides (p=0.105), total cholesterol (p=0.995), high-density lipoprotein (p=0.112), and low-density lipoprotein (0.506) p = ) and C-reactive protein (p = 0.965) did not show any significant difference between the research groups. But there was a significant difference in body weight (p=0.004), body mass index (p=0.010) and ratio of waist circumference to hip circumference (p=0.000) among research groups. Conclusion: 6 weeks of CXWORX training along with nettle supplementation can reduce body weight, body mass index and waist to hip ratio.Background and Aim: The aim of this study was to investigate the effect of 6 weeks of CXWORX training along with nettle supplement consumption on lipid profile, C-reactive protein and some body composition indicators of overweight and obese women. Methods: The current research was semi-experimental with a pre-test and post-test design. For this purpose, 48 overweight and obese women with an age range of 20-40 years and a body mass index (BMI) between 25-34 kg/m2 were purposefully selected and divided into 4 groups: exercise + nettle, exercise + placebo, nettle and Placebo was divided. All measurements were done one stage before the start of the course and another stage after the course was finished. After collecting the data, the data were analyzed with SPSS software, and Shapiro-Wilk, T-correlated tests and one-way analysis of variance were used at a significance level of p<0.05. Results: The results showed that after 6 weeks of intervention, the levels of triglycerides (p=0.105), total cholesterol (p=0.995), high-density lipoprotein (p=0.112), and low-density lipoprotein (0.506) p = ) and C-reactive protein (p = 0.965) did not show any significant difference between the research groups. But there was a significant difference in body weight (p=0.004), body mass index (p=0.010) and ratio of waist circumference to hip circumference (p=0.000) among research groups. Conclusion: 6 weeks of CXWORX training along with nettle supplementation can reduce body weight, body mass index and waist to hip ratio.https://jme.guilan.ac.ir/article_6369_ed7bd913dc0fea9a137cc4cf6c847d98.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923The effect of eight weeks of resistance and aerobic training on the levels of IGFBP 3, IGF1, and BMI in obese women of Ahvaz cityThe effect of eight weeks of resistance and aerobic training on the levels of IGFBP 3, IGF1, and BMI in obese women of Ahvaz city90105637510.22124/jme.2023.24048.279FAMinaShakhiDepartment of Sports Physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, IranAboalhamidHabibiDepartmant sport physiology، Shahid Chamran University، Ahvaz، Ahvaz،IranAliakbarAlizadehDepartment of Sports Physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, IranJournal Article20230307Introduction and purpose: The purpose of this research is to investigate the effect of exercise (resistance-aerobic) on the levels of IGFBP3, IGF1, and BMI in obese wome .Materials and methods: For this purpose, 24 inactive obese women aged 25 to 37 years with a BMI of 30 to 35 kg/m2 were randomly divided into two groups of 12 people, training and control. The selected exercise included resistance training with weights and a special bodybuilding machine with an intensity of 67 to 80% of the maximum strength and aerobic exercise with a stationary bike and an intensity of 60 to 85% of the maximum heart rate, for 8 weeks and 3 days a week. Body composition measurements were taken 24 hours before and 24 hours after exercise. For statistical analysis in the findings section, one-way analysis of covariance test was used to examine inter-group changes. Findings: The results of this study showed that after eight weeks of resistance and aerobic training, a significant decrease in the BMI of subjects in the training group was observed compared to the control group (P<0.001). Also, the results of analysis of covariance showed that after eight weeks of selected training (resistance-aerobic) the two indexes of IGFBP3 and IGF1 in the training group decreased significantly compared to the control group (P<0.001 and P<0.006, respectively). Conclusion: According to the results of this research, both resistance and aerobic training methods can be used to reduce weight, BMI, IGFBP3 and IGF1.Introduction and purpose: The purpose of this research is to investigate the effect of exercise (resistance-aerobic) on the levels of IGFBP3, IGF1, and BMI in obese wome .Materials and methods: For this purpose, 24 inactive obese women aged 25 to 37 years with a BMI of 30 to 35 kg/m2 were randomly divided into two groups of 12 people, training and control. The selected exercise included resistance training with weights and a special bodybuilding machine with an intensity of 67 to 80% of the maximum strength and aerobic exercise with a stationary bike and an intensity of 60 to 85% of the maximum heart rate, for 8 weeks and 3 days a week. Body composition measurements were taken 24 hours before and 24 hours after exercise. For statistical analysis in the findings section, one-way analysis of covariance test was used to examine inter-group changes. Findings: The results of this study showed that after eight weeks of resistance and aerobic training, a significant decrease in the BMI of subjects in the training group was observed compared to the control group (P<0.001). Also, the results of analysis of covariance showed that after eight weeks of selected training (resistance-aerobic) the two indexes of IGFBP3 and IGF1 in the training group decreased significantly compared to the control group (P<0.001 and P<0.006, respectively). Conclusion: According to the results of this research, both resistance and aerobic training methods can be used to reduce weight, BMI, IGFBP3 and IGF1.https://jme.guilan.ac.ir/article_6375_9cfe7a18f12b25ecb2d755107a4d2c0f.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923Response of Liver Tissue Oxidative Indices to Bisphenol-A intoxicated Rats to Eight Weeks of Aerobic Training with and without Zinc Supplementation (Zinc Nanoparticles and Nanoparticles)Response of Liver Tissue Oxidative Indices to Bisphenol-A intoxicated Rats to Eight Weeks of Aerobic Training with and without Zinc Supplementation (Zinc Nanoparticles and Nanoparticles)106129637910.22124/jme.2023.24007.270FAMohammadSalmasiDepartment of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran0009-0008-5233-069XAsgharTofighiDepartment of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, IranSiamakAsriDepartment of Internal Diseases and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, IranJavadTolouei AzarDepartment of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, IranJournal Article20230302Aims: The purpose of this study was to investigate the effect of moderate-intensity aerobic exercise with and without supplementation of nanoparticles and zinc oxide salts on hepatocyte oxidative markers in BPA-intoxicated rats.<br /><br />Methods: 60 male rats were divided into 12 groups: 1) Control; 2) BPA; 3) Exercise; 4) Exercise+BPA; 5) Nanoparticle supplementation (Nano); 6) Nanoparticle+BPA (Nano+BPA); 7) Zinc oxide salt (Zno); 8) Zinc oxide salt+BPA (Zno+BPA); 9) Exercise+Nano; 10) Exercise+Nano+BPA; 11) Exercise+Zno; and 12) Exercise+Zno+BPA. The exercise program was performed for eight weeks with 50-75% VO2max for 25 to 64 minutes. Nanoparticles supplemented give with 5 mg/kg 5 days a week for eight weeks.<br /><br />Results: The activity of the antioxidant enzymes GPX, SOD and Catalase increase significantly in the BPA group in addition to the increase in the exercise group, but TAC status decreased significantly in the exercise group alone (p = 0.001) and Zno and NanoZno groups significantly increased this index compared to the healthy control group (p = 0.001). Interestingly, in MDA and AOPP, the BPA groups showed a significant increase in these variables, supplementation caused a significant decrease in these variables, and the highest reduction was in BPA+Nano and BPA+Zno (p = 0.001).<br /><br />Conclusion: BPA causes reactive changes in antioxidant capacity, it destroys total antioxidant capacity. However, oxidative index studies revealed that a combination of moderate-intensity exercise and zinc oxide supplements (especially supplementation alone) may alter the kinetics of BPA contamination by inhibiting the oxidative system and subsequently improving hepatocyte status.Aims: The purpose of this study was to investigate the effect of moderate-intensity aerobic exercise with and without supplementation of nanoparticles and zinc oxide salts on hepatocyte oxidative markers in BPA-intoxicated rats.<br /><br />Methods: 60 male rats were divided into 12 groups: 1) Control; 2) BPA; 3) Exercise; 4) Exercise+BPA; 5) Nanoparticle supplementation (Nano); 6) Nanoparticle+BPA (Nano+BPA); 7) Zinc oxide salt (Zno); 8) Zinc oxide salt+BPA (Zno+BPA); 9) Exercise+Nano; 10) Exercise+Nano+BPA; 11) Exercise+Zno; and 12) Exercise+Zno+BPA. The exercise program was performed for eight weeks with 50-75% VO2max for 25 to 64 minutes. Nanoparticles supplemented give with 5 mg/kg 5 days a week for eight weeks.<br /><br />Results: The activity of the antioxidant enzymes GPX, SOD and Catalase increase significantly in the BPA group in addition to the increase in the exercise group, but TAC status decreased significantly in the exercise group alone (p = 0.001) and Zno and NanoZno groups significantly increased this index compared to the healthy control group (p = 0.001). Interestingly, in MDA and AOPP, the BPA groups showed a significant increase in these variables, supplementation caused a significant decrease in these variables, and the highest reduction was in BPA+Nano and BPA+Zno (p = 0.001).<br /><br />Conclusion: BPA causes reactive changes in antioxidant capacity, it destroys total antioxidant capacity. However, oxidative index studies revealed that a combination of moderate-intensity exercise and zinc oxide supplements (especially supplementation alone) may alter the kinetics of BPA contamination by inhibiting the oxidative system and subsequently improving hepatocyte status.https://jme.guilan.ac.ir/article_6379_61de1d969328784b0aeb1b12b7c544db.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923Effect of supplementation of L-arginine on platelet indices in response to a high intensity interval exercise in overweight menEffect of supplementation of L-arginine on platelet indices in response to a high intensity interval exercise in overweight men130142638010.22124/jme.2023.24036.276FASiamakRahbarPhD student of Tabriz University,SajadAhmadizadFaculty of Sports Sciences, Shahid Beheshti University, Tehran, IranHiwaRahmaniphd.Exercise PhysiologyJournal Article20230305Objective: To investigate the effect of L-arginine supplementation on platelet indices in response to a high intensity interval exercise.<br /><br />Methods: Ten healthy overweight young men (BMI=27 ± 1.2 kg/m2) participated voluntarily in this cross-over and double-blind study, and performed a high intensity interval exercise (HIIE) protocol with L-arginine supplementation or placebo, where, two trials were separated by seven days. In each session, the subjects consumed 0.075 g per kg body weight of supplement or placebo which was dissolved in 400 ml of water, and 90 minutes later, performed HIIE as 12 intervals of 3-minute on treadmill (activity: 1-min, 100% of vVO2max, recovery: 2-min, 40% of vVO2max). To measure platelet indices including mean platelet volume (MPV), platelet count (PLT), plateletcrit (PCT) and platelet distribution width (PDW), three blood samples were taken before supplementation and immediately before and after HIIE.<br /><br />Results: Regardless of the type of supplement, HIIE increased PLT and PCT by 29 and 31%, respectively (P < 001), but did not have a significant effect on MPV and PDW. Furthermore, consumption of L-arginine 90 min prior to HIIE, inhibited PCT (P = 0.043) but had no effect on PLT.<br /><br />Conclusion: Intermittent nature and recovery periods in HIIE protocol did not significantly increase MPV and PDW in both sessions, which may be a reason for the safety of the HIIE. L-arginine supplementation prior to HIIE only reduced PCT, due to its inability to affect other indices, to achieve more accurate results further studies with more effective doses of supplementation are needed.Objective: To investigate the effect of L-arginine supplementation on platelet indices in response to a high intensity interval exercise.<br /><br />Methods: Ten healthy overweight young men (BMI=27 ± 1.2 kg/m2) participated voluntarily in this cross-over and double-blind study, and performed a high intensity interval exercise (HIIE) protocol with L-arginine supplementation or placebo, where, two trials were separated by seven days. In each session, the subjects consumed 0.075 g per kg body weight of supplement or placebo which was dissolved in 400 ml of water, and 90 minutes later, performed HIIE as 12 intervals of 3-minute on treadmill (activity: 1-min, 100% of vVO2max, recovery: 2-min, 40% of vVO2max). To measure platelet indices including mean platelet volume (MPV), platelet count (PLT), plateletcrit (PCT) and platelet distribution width (PDW), three blood samples were taken before supplementation and immediately before and after HIIE.<br /><br />Results: Regardless of the type of supplement, HIIE increased PLT and PCT by 29 and 31%, respectively (P < 001), but did not have a significant effect on MPV and PDW. Furthermore, consumption of L-arginine 90 min prior to HIIE, inhibited PCT (P = 0.043) but had no effect on PLT.<br /><br />Conclusion: Intermittent nature and recovery periods in HIIE protocol did not significantly increase MPV and PDW in both sessions, which may be a reason for the safety of the HIIE. L-arginine supplementation prior to HIIE only reduced PCT, due to its inability to affect other indices, to achieve more accurate results further studies with more effective doses of supplementation are needed.https://jme.guilan.ac.ir/article_6380_4f4509d93919d626937dfabebfda3cfd.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923The effect of simulating staying at moderate altitude with thyme consumption on cardiomyopathy and liver enzymes in Rats with type 2 diabetesThe effect of simulating staying at moderate altitude with thyme consumption on cardiomyopathy and liver enzymes in Rats with type 2 diabetes143162638110.22124/jme.2023.24199.288FAMahdiFaramoushiهیات علمی0000-0002-3312-5307RaminAmirsasanExercise Physiology, Faculty of Physical Education and Sport Sciences, University of TabrizVahidSari SarrafExercise Physiology, Faculty of Physical Education and Sport Sciences, University of TabrizJournal Article20230329the aim of study was to investigate the effect of simulating staying at medium altitude along with consumption of thyme on the cardiomyopathy rate of type 2 diabetic rats and their simultaneous effect on liver enzymes.Methods: For this purpose, 40 Wistar rats were divided into five groups of eight. In order to induce type 2 diabetes, streptozotocin was injected intraperitoneally.Altitude group was alternately placed for eight weeks in night sleep conditions at a simulated altitude in a hypoxia chamber, and thyme group was supplemented with thyme in the form of 400 mg/kg of hydroalcoholic extract in 30 ml of drinking water. Cardiomyopathy was measured through two indices of apoptosis (western blot) and fibrosis (staining), and diabetic indices, liver enzymes using methods Calorimetry was measured by biochemistry company.<br /><br />Results: The results showed that 8 weeks of altitude and thyme reduce the fasting glucose level in diabetics (P<0.05). Also, the results of the multivariate analysis of variance test showed Apoptosis and fibrosis showed a significant decrease in myocardial with exposure to altitude and simultaneous consumption of thyme (p<0.025). Also, moderate altitude and consumption of thyme extract had no significant effect on the serum levels of ALT and AST transaminases.<br /><br />Conclusion: Simulated moderate altitude and consumption of thyme in this research decreased fasting blood sugar and on the other hand, by reducing apoptosis and fibrosis, it prevented cardiomyopathy in the heart of type 2 diabetic rats, but these two variables did not cause a significant decrease in ALT and AST enzymes.the aim of study was to investigate the effect of simulating staying at medium altitude along with consumption of thyme on the cardiomyopathy rate of type 2 diabetic rats and their simultaneous effect on liver enzymes.Methods: For this purpose, 40 Wistar rats were divided into five groups of eight. In order to induce type 2 diabetes, streptozotocin was injected intraperitoneally.Altitude group was alternately placed for eight weeks in night sleep conditions at a simulated altitude in a hypoxia chamber, and thyme group was supplemented with thyme in the form of 400 mg/kg of hydroalcoholic extract in 30 ml of drinking water. Cardiomyopathy was measured through two indices of apoptosis (western blot) and fibrosis (staining), and diabetic indices, liver enzymes using methods Calorimetry was measured by biochemistry company.<br /><br />Results: The results showed that 8 weeks of altitude and thyme reduce the fasting glucose level in diabetics (P<0.05). Also, the results of the multivariate analysis of variance test showed Apoptosis and fibrosis showed a significant decrease in myocardial with exposure to altitude and simultaneous consumption of thyme (p<0.025). Also, moderate altitude and consumption of thyme extract had no significant effect on the serum levels of ALT and AST transaminases.<br /><br />Conclusion: Simulated moderate altitude and consumption of thyme in this research decreased fasting blood sugar and on the other hand, by reducing apoptosis and fibrosis, it prevented cardiomyopathy in the heart of type 2 diabetic rats, but these two variables did not cause a significant decrease in ALT and AST enzymes.https://jme.guilan.ac.ir/article_6381_0241b3051b12353f6814194f3d876640.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923Comparison of the effect of eight weeks aerobic exercises and 10-20-30 on serum levels of spexin and lipid profile indices of obese menComparison of the effect of eight weeks aerobic exercises and 10-20-30 on serum levels of spexin and lipid profile indices of obese men163179638210.22124/jme.2023.24213.290FARoghayehFakhrpourDepartment of Sport Sciences, Faculty of Educational Sciences and Psychology, Azarbaijan Shahid Madani University, Tabriz, IranHamidYazdanshenas. Department of Sports Sciences, Faculty of Educational Sciences and Psychology, Shahid Madani University of Azerbaijan, Tabriz, Iran.Journal Article20230401Aim: choosing the type of sports activity for better effect in obese people can be considered as an important factor and challenge. On the other hand, Spexin plays a central and peripheral role in regulating satiety and food intake, motility of the digestive tract, energy metabolism and glucose/lipid metabolism. Therefore, the present study was conducted with the aim of comparing the effect of eight weeks of aerobic exercise and 30-20-10 on serum levels of spexin and lipid profile indices of obese men. <br /><br />Methods: The present experimental study and its statistical sample were 30 obese men who were randomly assigned to two groups of aerobic exercise and 30-20-10 exercise (15 people in each group). Aerobic exercise and 30-20-10 exercise were performed for eight consecutive weeks. Before and after the start of the protocol, height, weight, maximum oxygen consumption blood sampling from the brachial vein were performed to evaluate the amount of spexin and lipid profile.<br /><br />Results: The inter-group results showed that there was a significant difference in the levels of SPX and total cholesterol between the two groups of aerobic exercise and 30-20-10 exercise, so that by examining the difference in means, the greatest effect was after aerobic exercise. P = 0.001 and P = 0.005). But HDL levels were not significantly different between the two groups (P=215).<br /><br />Conclusion: According to the results of the present study, it is likely that aerobic exercise has a better effect on the serum levels of spexin and cholesterol in obese people than 10-20-30 exercises.Aim: choosing the type of sports activity for better effect in obese people can be considered as an important factor and challenge. On the other hand, Spexin plays a central and peripheral role in regulating satiety and food intake, motility of the digestive tract, energy metabolism and glucose/lipid metabolism. Therefore, the present study was conducted with the aim of comparing the effect of eight weeks of aerobic exercise and 30-20-10 on serum levels of spexin and lipid profile indices of obese men. <br /><br />Methods: The present experimental study and its statistical sample were 30 obese men who were randomly assigned to two groups of aerobic exercise and 30-20-10 exercise (15 people in each group). Aerobic exercise and 30-20-10 exercise were performed for eight consecutive weeks. Before and after the start of the protocol, height, weight, maximum oxygen consumption blood sampling from the brachial vein were performed to evaluate the amount of spexin and lipid profile.<br /><br />Results: The inter-group results showed that there was a significant difference in the levels of SPX and total cholesterol between the two groups of aerobic exercise and 30-20-10 exercise, so that by examining the difference in means, the greatest effect was after aerobic exercise. P = 0.001 and P = 0.005). But HDL levels were not significantly different between the two groups (P=215).<br /><br />Conclusion: According to the results of the present study, it is likely that aerobic exercise has a better effect on the serum levels of spexin and cholesterol in obese people than 10-20-30 exercises.https://jme.guilan.ac.ir/article_6382_cbc59010b3a05b801d3092b7b2700473.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923The effect of 70 percent reduction in training load during the tapering on serum levels of cortisol , testosterone , the ratio of testosterone to cortisol and performance changes in trained swimmersThe effect of 70 percent reduction in training load during the tapering on serum levels of cortisol , testosterone , the ratio of testosterone to cortisol and performance changes in trained swimmers180192638310.22124/jme.2023.23945.244FAAghaaliGhasemnianAssociate Professor, of University of Zanjan, Zanjan, IranAhmadAzadDepartment of physical education Bandar Anzali Branch, Islamic Azad University, Bandar Anzali, Islamic Republic of IranMohamadrezaSeraji VatanMaster student Department of Sport Sciences, Faculty of Humanities, University of Zanjan, Zanjan , Iran - - Department of Sport Sciences, Faculty of Humanities, University of Zanjan, Zanjan , IranJournal Article20230226Introduction: The purpose of this study was to determine the effect of 70percent reduction in training loade during the tapering on serum levels of cortisol, testosterone and performance changes in trained swimmers<br /><br />Methods: In this quasi-experimental study, 20 trained male swimmers were selected by available sampling method and participated voluntarily in the study. Then based on the record of 200m freestyle, the subjects were divided into two groups: Taper(n=10) and control(n=10). Both groups initially Participated in6 weeks in incremental exercises training. Then the taper group spent the 14-day period with a 70% reduction in training load and the control group continued training with the same load as before. In both groups, performance tests (upper and lower body strength) and blood samples (for measurement of serum testosterone, cortisol and testosterone / cortisol ratio) were taken at the beginning of the taper and after the end of this period. For determination of testosterone and cortisol levels, ELISA kits was used. Data were analyzed using, paired t-, and covariance tests. <br /><br />Results: The results indicated that after the tapering , there was a significant difference between the two groups in swimming performance (200m freestyle), upper and lower strength, serum cortisol levels, and the ratio of testosterone to cortisol(P< 0/05). However, there was no significant difference in testosterone levels between the two groups(P> 0/05).<br /><br />Conclusion: The findings of this study showed that taper plan with 14-days, improved anabolic conditions and performance in trained swimmers.Introduction: The purpose of this study was to determine the effect of 70percent reduction in training loade during the tapering on serum levels of cortisol, testosterone and performance changes in trained swimmers<br /><br />Methods: In this quasi-experimental study, 20 trained male swimmers were selected by available sampling method and participated voluntarily in the study. Then based on the record of 200m freestyle, the subjects were divided into two groups: Taper(n=10) and control(n=10). Both groups initially Participated in6 weeks in incremental exercises training. Then the taper group spent the 14-day period with a 70% reduction in training load and the control group continued training with the same load as before. In both groups, performance tests (upper and lower body strength) and blood samples (for measurement of serum testosterone, cortisol and testosterone / cortisol ratio) were taken at the beginning of the taper and after the end of this period. For determination of testosterone and cortisol levels, ELISA kits was used. Data were analyzed using, paired t-, and covariance tests. <br /><br />Results: The results indicated that after the tapering , there was a significant difference between the two groups in swimming performance (200m freestyle), upper and lower strength, serum cortisol levels, and the ratio of testosterone to cortisol(P< 0/05). However, there was no significant difference in testosterone levels between the two groups(P> 0/05).<br /><br />Conclusion: The findings of this study showed that taper plan with 14-days, improved anabolic conditions and performance in trained swimmers.https://jme.guilan.ac.ir/article_6383_2f11efbe83d56a15d446ddfb12376fe2.pdfUniversity of GuilanMetabolism and Exercise2322-286712220220923Effect of Six-Week Resistance Training on Fertility indices in Obese Male StudentsEffect of Six-Week Resistance Training on Fertility indices in Obese Male Students193206644810.22124/jme.2023.24123.285FAElnazSadeghpour FirozabadiDepartment of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, IranAlirezaBararidepartment of sport physiology,ayatollah amoli branch,,islamic azad universityJournal Article20230315Aim: Changes in the hypothalamo-pituitary axis are probably related to changes in sex hormones. Physical training is one of the effective factors in the changes of this axis. purpose of this study was the effect of six weeks of ResistanceTraining on free Testosterone serum levels, sex hormones binding globuline, Inhibin b and luteinizing and follicle-stimulating hormone in obese men students. Methods: For this purpose, 20 obese male students with aged range of 20 ± 2 years participated in this study and divided randomly into 2 groups 10 people of resistance training and control. Resistance training was performed for six weeks and three sessions per week in %60 to %70 repetition maximun. In order to analyze the biochemical variables, blood samples were taken at two stages, 48 hours before and after of training period. Inter group and between changes of information were performed by dependent and independent t-test. Results: The results of this study showed that resistance training led to a significant increase in free testosterone serum concentration and a significant increase in SHBG in obese men. But after six weeks of training, there were no significant changes in inhibin b, luteinizing hormone and follicular stimulation hormone. Conclusion: six weeks of resistance training with improved body composition, upper and lower body muscle strength and also aerobic power are associated with changes in sex hormones in obese men.Aim: Changes in the hypothalamo-pituitary axis are probably related to changes in sex hormones. Physical training is one of the effective factors in the changes of this axis. purpose of this study was the effect of six weeks of ResistanceTraining on free Testosterone serum levels, sex hormones binding globuline, Inhibin b and luteinizing and follicle-stimulating hormone in obese men students. Methods: For this purpose, 20 obese male students with aged range of 20 ± 2 years participated in this study and divided randomly into 2 groups 10 people of resistance training and control. Resistance training was performed for six weeks and three sessions per week in %60 to %70 repetition maximun. In order to analyze the biochemical variables, blood samples were taken at two stages, 48 hours before and after of training period. Inter group and between changes of information were performed by dependent and independent t-test. Results: The results of this study showed that resistance training led to a significant increase in free testosterone serum concentration and a significant increase in SHBG in obese men. But after six weeks of training, there were no significant changes in inhibin b, luteinizing hormone and follicular stimulation hormone. Conclusion: six weeks of resistance training with improved body composition, upper and lower body muscle strength and also aerobic power are associated with changes in sex hormones in obese men.https://jme.guilan.ac.ir/article_6448_0c5a9edb3b4632b411530760aefbe834.pdf