Exercise Physiology
hamid malekshahiniya; Roohollah Mohammadi Mirzaei; Halimeh vahdatpoor; M Azarniveh
Abstract
Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide ...
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Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05. Results: The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01). Conclusion: The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients.
