Exercise Physiology
Fateme Mokhtari; Elahe Talebi Garakani; Khadije Nasiri; Abolfazl Akbari
Abstract
Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.Method: Male rats were initially divided into ...
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Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.Method: Male rats were initially divided into 2 groups: normal and exposed to dexamethasone. Dexamethasone group were randomly divided into 6 groups. control (C), Silymarin (S), continues training (CT), and continues training+silymarin (CTS), high intensity interval training (HIT), high intensity interval training+Silymarin (HITS). Silymarin groups, received 300 mg. kg-1.d-1 of silymarin solution through gavage. Animals in HIT groups performed 3-min bouts at 40 m/min, interspersed by 3-min active recovery at a running velocity of 20 m/min on a motorized treadmill with 15% incline, repeated six times per session. Continues training groups performed steady state running at the same speed as the active recovery's speed in the HIT group. Liver histological modifications and serum levels of alanine aminotransferase (ALT) and Aspartate transaminase (AST) were measured. Results: Silymarin consumption and aerobic training were able to improve histological changes compared with control group. Interactive effect of silymarin supplementation and training on AST and ALT levels was not significant. Silymarin reduced liver AST and ALT levels (p≤0.05). Also, AST levels were significantly higher in HIT group than in control group (p≤0.05). The amount of this enzyme in the HITS was significantly reduced compared to HIT group (p≤0.05). Conclusion: Silymarin supplementation and aerobic training separately and in combination may improve liver histological status of rats with dexamethasone-induced nonalcoholic fatty liver.
Masoud Shakki; Fatemeh Hosseini; Saeed Ghorbani; reza rezai shirazi; H parsian
Abstract
Aim: The purpose of the study was to investigate the effect of 8 weeks of aerobic interval exercise with silymarin supplementation on antioxidant, liver damage and atherogenic indicators in male Wistar rats fed a high-fat diet.Methods: This experimental study with laboratory method was performed on 35 ...
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Aim: The purpose of the study was to investigate the effect of 8 weeks of aerobic interval exercise with silymarin supplementation on antioxidant, liver damage and atherogenic indicators in male Wistar rats fed a high-fat diet.Methods: This experimental study with laboratory method was performed on 35 male Wistar rats with a body weight of 160.45±7.08g and 3-weeks-of-age were randomly divided into 5 groups consisted of ordinary diet control (ODC), fatty diet control (FDC), fatty diet with supplement (FDS), fatty diet with exercise (FDE), fatty diet with supplement and exercise (FDSE). The exercises included the running on treadmill for 8 weeks, five times/week and 30 minutes in an exercise session. Silymarin supplementation with dose of 140 mg/kg/day of body, weight was received for two weeks. Liver tissue and samples were obtained after 48 hours of the last diet and data analyzed. Results: Significant decrease in FDSE and FDE groups compared with FDC group in ALT, AST, and ALP, MDA, TC and TG variables were observed. Whereas, there were significantly increased in FDSE group compared with FDC in SOD and HDL-C variables. Also, LDL-C and AIP in FDSE group compared with FDC had shown a significant decrease (p> .05).Conclusion: The applying of aerobic interval exercise alone or with silymarin supplementation reduced the risk to NAFLD such as enzymes involved and atherogenic index in male Wistar rats fed a high-fat diet; therefore, it could probably improve the disease through increase the antioxidant capacity and reduce blood lipid profiles.
