Nasrin Ramzany; Abasali Gaeini; Sirou Choobineh; Mohamadreza Kordi; Mehdi Hedayati
Volume 5, Issue 2 , February 2016, , Pages 89-98
Abstract
Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 ...
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Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 g) were selected as sample research. Diabetes was induced by using nikotinamid and streptozotocin. Five days after inducing diabetes, fasting blood was measured using blood glucose strips and rats that the level of fasting blood glucose was between 400-126 mg was selected as diabetic. Rats were randomly and According to homogenization of body weight assigned into two groups including control (n=9) and trained (n=9).Rats in the training groups carried out an 8-week exercise program on a motorized treadmill with 10–25 m/min for 15-40 min/day and a 5% slope for 5 days. Serum RBP4 levels was measured with Elisa method and insulin resistance was measured by HOMA-IR index. Results: Induction of diabetes caused a significant increase in body weight (p=0.001) and serum RBP4 (p<0.05). Also exercise caused a significant increase in muscle weight in the training group (p<0.05). Serum RBP4 levels after training significantly decreased in comparison with control groups (p<0.05). Also glucose, insulin and insulin resistance index were significantly decreased in the training group compared with the control group (p<0.05). Conclusion: it seems that 8 weeks aerobic training with 60-80% vo2max can be effective to decrease the serum RBP4 levels and insulin resistance index in type 2 diabetic patients.
Karim Azali Alamdari; Farhad Gholami
Volume 5, Issue 2 , February 2016, , Pages 109-119
Abstract
Aim: Retinol binding protein-4 (RBP-4) as an adipokine secreted from adipose tissue, plays an important role in insulin resistance and metabolic disorders. Despite the benefits of aerobic training on metabolic disorders, the effect of aerobic training on RBP-4 and its relation with metabolic factors ...
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Aim: Retinol binding protein-4 (RBP-4) as an adipokine secreted from adipose tissue, plays an important role in insulin resistance and metabolic disorders. Despite the benefits of aerobic training on metabolic disorders, the effect of aerobic training on RBP-4 and its relation with metabolic factors in patients with metabolic syndrome is unclear. Therefore, the aim of this study was to investigate the effect of eight weeks aerobic training on serum RBP-4 levels and insulin resistance in women with metabolic syndrome. Methods: In a semi-experimental study, 24 women with metabolic syndrome (age: 52.79±4.91 yrs, BMI: 32.77±2.37 Kg/m2 and VO2peak: 40±2.55 L/min) were randomly assigned into two groups including exercise (n=12) and control (n=12) groups. Aerobic exercise program was performed for 8 weeks, 3 sessions per week with an intensity of 50-60% of peak oxygen consumption for 20-40 minutes. Prior to the experimental period and 48h after last training session, body composition measurements were performed and blood samples were taken to be measured for serum levels of RBP-4, lipid profile, glucose and insulin. Insulin resistance index was also assessed. The data were analyzed using statistical tests of Paired and Independent t-test and Pearson's correlation test at significance level of PResults: The results showed that aerobic training significantly decreased serum RBP-4, glucose, insulin resistance index, body weight, body fat percentage, body mass index (BMI), waist circumference and metabolic syndrome Z score (P<0.05). Moreover, high density lipoprotein HDL - C levels significantly increased following eight weeks aerobic training (P<0.05). Pearson's correlation test revealed that changes in RBP-4 levels was significantly correlated with changes in body fat percentage, triglycerides, insulin and insulin resistance index (P<0.05). Conclusion: Overall, the results of this study indicated that aerobic training can reduce the RBP-4 levels and improve insulin resistance and some metabolic risk factors in women with metabolic syndrome. Insulin resistance improvement is likely to be resulted from decreased RBP-4 levels following aerobic training.
