Exercise Metabolism
nasrin ramezani; mahshid dezhan; Seyed Amirhossein Mortazavi; Mozhgan Baghaee Borzabadi; zahra ahadi; Saeideh Sadat Khalili
Abstract
Diabetes is the most common endocrine disease in the world, and various methods such as exercise and physical activity are used to treat it. the aim of this study was to determine the effect of high-intensity interval training on serum glucose, insulin ,irisin and its gene expression in subcutaneous ...
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Diabetes is the most common endocrine disease in the world, and various methods such as exercise and physical activity are used to treat it. the aim of this study was to determine the effect of high-intensity interval training on serum glucose, insulin ,irisin and its gene expression in subcutaneous adipose tissue in type 2 diabetic rats. For this study, 20 males of the wistar male rat (8-10 weeks with a weight of 250-270 g) were selected and randomly divided into two groups of diabetic control and diabetic exercise. After the introductory course, the experimental group performed high-intensity exercise for 4 weeks, 5 days a week for 10 minutes as 1-minute interval at a speed of 30-40 meters per second. 48 hours after the last training session and after 12 hours of fasting, glucose and insulin values serum values and expression of irisin gene were measured in subcutaneous adipose tissue. Data were analyzed using independent t-test. The results showed that 4 weeks of high-intensity interval training reduced serum glucose levels and insulin resistance index (p = 0.001), significantly increased serum values (p = 0.001) and expressed irisin gene (P = 0.004) in subcutaneous adipose tissue was controlled in the exercise group compared to the group.High-intensity interval training can reduce serum glucose levels and insulin resistance index in type 2 diabetic rats and increase serum levels and irisin gene expression in adipose tissue. it is suggested to use this type of exercises to reduce the problems caused by type 2 diabetes.
Exercise Physiology
maryam Molaei Jeghanab; mandana gholami; Abdolali Banaeifar; Farshad Ghazalian
Abstract
Aim: Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating ...
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Aim: Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating with pathologic effects of type 2 diabetes. The aim of present study is to determine the effect of eight weeks resistance training along withvitaminD consumption on levels of chemerin and omentin-1 in type 2 diabetic patientsMethod: 40 diabetics men with average age of 47.19±3.83 years old and body fat percentage 30.96±2.49 assigned in four groups including the placebo, vitaminD, training and training+ vitaminD groups. The resistance training program conducted for eight weeks and three session per week with 60 to 70 percent of 1RM intensity. VitaminD consumption considered daily 2000 iu and placebo (oral paraffin) ingestion considered in the same amount. At the baseline and ending intervention, blood samples collected and the levels of chemerin and omentin-1 were measured and insulin resistance calculated. Data were analyzed by analysis of covariance test and Bonferroni post-hoc test.Results: The present study findings indicated that in training and training+vitaminD groups the chemerin levels significantly decreased and omentin-1 significantly increased (p<0.05). Moreover, significant decrease of insulin resistance was observed in training and training+vitaminD groups (p<0.05).Conclusion: VitaminD ingestion can increase the hypoglycemic effects of resistance training partly, which these positive effects of resistance training and vitaminD consumption exerted by increase in omentin1 levels and decrease of chemerin levels.
Exercise Physiology
hamid malekshahiniya; Roohollah Mohammadi Mirzaei; Halimeh vahdatpoor; M Azarniveh
Abstract
Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide ...
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Background: The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes. Methodology: In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05. Results: The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01). Conclusion: The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients.
hamideh montazery taleghani; nader shakeri; khosrow ebrahim; rahman soori; M Gholami
Abstract
Background: A main reason of death in diabetes is cardiovascular diseases, which apoptosis plays a critical role through the progress. As known, body exercises can avoid damaging effects of apoptosis on human heart. This study is investigating the effects of resistance exercises in a period of 8 weeks ...
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Background: A main reason of death in diabetes is cardiovascular diseases, which apoptosis plays a critical role through the progress. As known, body exercises can avoid damaging effects of apoptosis on human heart. This study is investigating the effects of resistance exercises in a period of 8 weeks on cardiomyocyte apoptosis status in streptozotocin induced diabetic rats..Materials and methods:20 male wistar rats with age of 8 weeks and 210-250 g weight randomly allocated into two groups. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg) in diabetic groups. The resistance training carried out a step ladder, load of 30-100 percentage of weight whereas control group remained sedentary. Measuring training adaptations blood and heart tissue samples were taken bout The level of the serum glucose, insulin, insulin resistance index, and gene expression levels Bcl-2,Bax,caspase8 and the ratio of bax/ Bcl-2 were assessed. Results: Implementation of 8 weeks of resistance exercise resulted significant decrease in gene expression levels Bax and the ratio of bax/ Bcl-2 (p=0/000)and a significant increase in Bcl-2(p=0/000) and caspase 8 (p=0/004) compare with control group in diabetic rats.Conclusion: The results show that resistance exercise may be used as a non‐pharmacological strategy to reduce the diabetes‐induced apoptosis in the heart in diabetes disease. Keyword:Type 2 diabetes,apoptosis,resistance exercise, gene expression
A Abbasi; M Faramarzi; M Ghatreh Samani; E Bbanitalebi
Abstract
Aim: NLRP-3 Inflammasome is considered an indicator of chronic diseases such as obesity and type 2 diabetes mellitus (T2DM) which can result in secretion of IL-1β from adipose tissue. Despite numerous investigations on the underlying activation mechanisms of NLRP-3 in pathogenesis of T2DM, less ...
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Aim: NLRP-3 Inflammasome is considered an indicator of chronic diseases such as obesity and type 2 diabetes mellitus (T2DM) which can result in secretion of IL-1β from adipose tissue. Despite numerous investigations on the underlying activation mechanisms of NLRP-3 in pathogenesis of T2DM, less attention has been paid to the impact of exercise on NLRP-3. Method: Male stereptpzosin-induces diabetic rats (n=40) were randomly assigned to five groups (n=8): diabetic+ low intensity endurance training (DL), diabetic+ moderate intensity endurance training (DM), diabetic+ high intensity endurance training (DH), non-diabetic with no training(CON), and diabetic with no training(D). Eight weeks of running (four sessions per week) with different intensities were completed. Western blotting method was used to measure NLRP3. ELISA technique was used to assess serum levels of insulin and glucose. Results: Results showed that expression of NLRP-3 protein were significantly lower in endurance DM (P<0.05) and endurance DH (P<0.05) groups against DL group. Caspase-1 expression was significantly lower in DL (P=0.001), DM (P<0.05), and DH (P<0.05) compared with D group. However, no significant different was found between the training groups. Serum insulin level was significantly lower in endurance DH group compared with endurance DL group (P<0.05).In comparison with D group, significant reduction of serum glucose was observed in endurance DL group (P<0.05), endurance DM (P<0.05), and endurance DH (P<0.05). Conclusion: It appears that training with high and moderate intensities induced positive modulation in NLRP-3 expression as well as improved glycemic factors levels.
Nasrin Ramzany; Abasali Gaeini; Sirou Choobineh; Mohamadreza Kordi; Mehdi Hedayati
Volume 5, Issue 2 , February 2016, , Pages 89-98
Abstract
Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 ...
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Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 g) were selected as sample research. Diabetes was induced by using nikotinamid and streptozotocin. Five days after inducing diabetes, fasting blood was measured using blood glucose strips and rats that the level of fasting blood glucose was between 400-126 mg was selected as diabetic. Rats were randomly and According to homogenization of body weight assigned into two groups including control (n=9) and trained (n=9).Rats in the training groups carried out an 8-week exercise program on a motorized treadmill with 10–25 m/min for 15-40 min/day and a 5% slope for 5 days. Serum RBP4 levels was measured with Elisa method and insulin resistance was measured by HOMA-IR index. Results: Induction of diabetes caused a significant increase in body weight (p=0.001) and serum RBP4 (p<0.05). Also exercise caused a significant increase in muscle weight in the training group (p<0.05). Serum RBP4 levels after training significantly decreased in comparison with control groups (p<0.05). Also glucose, insulin and insulin resistance index were significantly decreased in the training group compared with the control group (p<0.05). Conclusion: it seems that 8 weeks aerobic training with 60-80% vo2max can be effective to decrease the serum RBP4 levels and insulin resistance index in type 2 diabetic patients.
