hamed rashidi; Najmeh Rezaeian
Abstract
Aim: Steroid Receptor RNA Activator (SRA) is one of long non-coding RNA (LncRNA) playing a dual role glucose homeostasis and insulin resistance. Purpose of this study was to investigate ...
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Aim: Steroid Receptor RNA Activator (SRA) is one of long non-coding RNA (LncRNA) playing a dual role glucose homeostasis and insulin resistance. Purpose of this study was to investigate the effect of eight weeks of combined aerobic and resistance training (ART) on adipose tissue levels of SRA and insulin resistance index (HOMA-IR) in old rats. Twenty old female rat (24-28 weeks old, 379/20±13/30 gr) selected and were randomly divided into experimental and control groups (10 ones in each). The rats in the experimental group participated in eight weeks of ART, six days a week. Aerobic training consisted of running on a treadmill at low to moderate intensity (40-60% of the maximum speed obtained in the maximum running test), 60 minutes per session. Resistance training compromised climbing a ladder at an intensity equal to 40-60% of the force obtained in the maximum load test, 15 repetitions with a one-minute rest interval, and 45 minutes per session. Eight weeks of ART resulted in significant increases in adipose tissue levels of SRA in addition to significant decreases in levels of insulin and fasting blood glucose , HOMA-IR and body weight in the experimental group compared to the control group. Furthermore, eight weeks of ART caused in significant decreases in body weight in post-test compared to pre-test. it seems that eight weeks of combined aerobic and resistance training plays a role in improving insulin resistance and body composition despite of increasing SRA levels.
