Exercise Physiology
Fatemeh Beiksay Afshar; Esmaeil Nasiri; Ali Samadi
Abstract
Aim: The purpose of this study was to investigate the effect of sprint interval training on hippocampal oxidative stress markers hippocampus of adult male Wistar rats.Method: This is an experimental study in which 16 male Wistar rats were obtained, and after environmental adaptation and reaching target ...
Read More
Aim: The purpose of this study was to investigate the effect of sprint interval training on hippocampal oxidative stress markers hippocampus of adult male Wistar rats.Method: This is an experimental study in which 16 male Wistar rats were obtained, and after environmental adaptation and reaching target weight range randomly divided into two equal groups: control (CO) and sprint interval training (SIT). The SIT was performed for 8 weeks, 3 sessions per week, 4-9 repetitions of 10 seconds with 60 secs of active recovery between intervals. Forty-eight hours after the last exercise session the rats were anesthetized and the hippocampus was dissected and level of malondialdehyde (MDA) and superoxide dismutase (SOD), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) were assessed in hippocampus homogenate. The independent samples T test was used for data analysis (P<0.05).Results: There were no significant difference between the SIT and CO groups in the hippocampal GPx, TAC and MDA levels (p < 0.05). However, the activity level of SOD in the SIT group was significantly higher than the CO group (p<0.05).Conclusion: The present research revealed that despite its strenuous nature, SIT did not induce oxidative stress in the hippocampus and trend of changes in GPx and TAC, as well as observed significant increase in SOD activity levels suggests that it may have favorable effects on hippocampus oxidative- antioxidative status.
Faegheh Khosh-khahesh; Marefat Siahkohian; Babak Nokhostin Rohi
Volume 1, Issue 1 , April 2011, , Pages 23-32
Abstract
AbstractAim: The purpose of this study was to examine the effect of acute celecoxib administration on exercise-induced inflammation and lipid peroxidation markers.
Method: Twenty untrained, healthy male (age; 25.5±4.5 yr, weight; 72.8±7.9 kg, height; 177.3± 7.2 cm) were randomly assigned to treatment ...
Read More
AbstractAim: The purpose of this study was to examine the effect of acute celecoxib administration on exercise-induced inflammation and lipid peroxidation markers.
Method: Twenty untrained, healthy male (age; 25.5±4.5 yr, weight; 72.8±7.9 kg, height; 177.3± 7.2 cm) were randomly assigned to treatment (T) and placebo (P) groups. Blood samples were taken before, immediately, 3h and 24h after exercise. Subjects ran for 30 minutes with 75% VO2max on treadmill and 100 mg celecoxib and placebo administrated immediately and 12h after the second blood sampling to T and P groups respectively. White blood cells (WBC) and creatine kinas (CK) were measured by an autoanalyzer and malondealdehyde (MDA) by HPLC. Data were analyzed using repeated measures analysis of variance (ANOVA) with bonferoni correction and unpaired t-test.
Results: WBC levels were significantly increased 3h and decreased 24h after exercise in both groups (P≤0.05), while there was no difference between the two groups, though WBC levels were lower 24h after exercise in the T group than P group. CK levels were significantly increased immediately, 3h and 24h after exercise in both groups (P≤0.05), but there was no difference between the two groups, though CK levels were increased 24h after exercise in the T group than P group. MDA levels were significantly increased immediately after exercise in both groups (P≤0.05) but there was no difference between the two groups, though MDA levels were increased 24h after exercise in T group than P group.
Conclusion: Acute celecoxib administration could not affect inflammation and oxidative stress markers.Key words: Celecoxib, Lipid peroxidation, Inflammation
