Exercise Physiology
Fateme Mokhtari; Elahe Talebi Garakani; Khadije Nasiri; Abolfazl Akbari
Abstract
Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.Method: Male rats were initially divided into ...
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Objectives: The purpose of this study was to evaluate the effect of continuous and high intensity interval training with silymarin consumption on liver enzymes and histological modifications in rats with dexamethasone-induced nonalcoholic fatty liver disease.Method: Male rats were initially divided into 2 groups: normal and exposed to dexamethasone. Dexamethasone group were randomly divided into 6 groups. control (C), Silymarin (S), continues training (CT), and continues training+silymarin (CTS), high intensity interval training (HIT), high intensity interval training+Silymarin (HITS). Silymarin groups, received 300 mg. kg-1.d-1 of silymarin solution through gavage. Animals in HIT groups performed 3-min bouts at 40 m/min, interspersed by 3-min active recovery at a running velocity of 20 m/min on a motorized treadmill with 15% incline, repeated six times per session. Continues training groups performed steady state running at the same speed as the active recovery's speed in the HIT group. Liver histological modifications and serum levels of alanine aminotransferase (ALT) and Aspartate transaminase (AST) were measured. Results: Silymarin consumption and aerobic training were able to improve histological changes compared with control group. Interactive effect of silymarin supplementation and training on AST and ALT levels was not significant. Silymarin reduced liver AST and ALT levels (p≤0.05). Also, AST levels were significantly higher in HIT group than in control group (p≤0.05). The amount of this enzyme in the HITS was significantly reduced compared to HIT group (p≤0.05). Conclusion: Silymarin supplementation and aerobic training separately and in combination may improve liver histological status of rats with dexamethasone-induced nonalcoholic fatty liver.
Exercise Physiology
Fahimeh Mehrabani; farhad rahmani nia; Javad Mehrabani; Nasrin Razavianzadeh
Abstract
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which the accumulation of fat in the liver increases. Exercise training can improve the condition by preventing excessive accumulation of fat in the liver as a non-pharmacological intervention and preventing the progression of ...
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Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which the accumulation of fat in the liver increases. Exercise training can improve the condition by preventing excessive accumulation of fat in the liver as a non-pharmacological intervention and preventing the progression of the disease to chronic liver disease. The aim of this study was to compare the effect of combined exercises training with two intensities on FGF-21, insulin resistance, liver enzymes and body composition of women with fatty liver.Materials and Methods: 33 women with NAFLD with a mean age of 57.7 ± 45.43 years and a body mass index of 84.32 6 6 kg/m2 randomly divided into three equal groups; aerobic interval training (AIT); high intensity interval training (HIIT); and controls. The training program was performed for 12 weeks and 3 sessions per week. The variables were measured before and after the training program. Data were analyzed using analysis of variance with repeated measures (p< 0.05). Results: The results showed that HOMA-IR index and serum FGF-21 were significantly reduced in the combined training groups compared to the control (p<0.05). No significant effect or difference was observed in ALT and AST enzyme levels. Also, a significant decrease in body fat percentage was observed (p<0.05). Conclusion: It seems that women with NAFLD are likely to be able to use both combined resistance training intensity and moderate to severe interval as a non-pharmacological solution to reduce fat percentage and improve insulin and FGF-21 resistance.
Hasan Naghizadeh; kamal Azizbeigi
Abstract
Aim:Obesity is known as an inflammatory systemic indicator of various diseases. The aim of the present study was to investigate the effect of 12 weeks of progressive resistance exercise on serum levels of enzymes aspartate aminotransferase, alkaline phosphatase and alanine aminotransferase in obese men. ...
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Aim:Obesity is known as an inflammatory systemic indicator of various diseases. The aim of the present study was to investigate the effect of 12 weeks of progressive resistance exercise on serum levels of enzymes aspartate aminotransferase, alkaline phosphatase and alanine aminotransferase in obese men. Method:Forty sedentary obese men (BMI=31.07 kg.m2) with age range of 30-45 years were purposefully selected and randomly divided into two groups of 20 participants: progressive resistance exercise and control. The exercise protocol for 12 weeks, was carried out three times a week (First week:15 repetitions -2 rounds -50% 1RM; Twelfth week:12 repetitions -3 rounds -80% 1RM). Blood samples were taken before and 24 hours after the last training session to determine serum concentrations of aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase. Data were analyzed using independent and dependent t-test at a significance level of α=0.05. Results:The results showed that 12 weeks of progressive resistance training has significant effect on between group changes of aspartate aminotransferase(p=0.003), alkaline phosphatase (p=0.014), alanine aminotransferase(p=0.040) and the ratio of aspartate aminotransferase to alanine aminotransferase(p=0.006) in sedentary obese men. Significant between group changes were observed in muscle strength(p=0.001) and body fat percentage(p=0.038). Progressive resistance training is likely to reduce the concentration of aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase in the blood of obese obese men by improving body composition, muscle strength, and oxygen consumption. Conclusion:Progressive resistance training, possibly with improved body composition and muscle strength, can decrease the concentration of aspartate aminotransferase, alkaline phosphatase, and alanine aminotransferase in sedentary obese men.
Shadmehr Mirdar; Maedehsadat Raisi; Masoomeh Nobahar
Volume 1, Issue 1 , April 2011, , Pages 11-23
Abstract
AbstractAim: The objective of this research was to investigate the effect of two peaks exercise training program during one week on some hepatic stress indexes (AST, ALT) in active girls.
Method: Twelve physical education girl students with ranged between 16-18 years old and mean maximal oxygen consumption ...
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AbstractAim: The objective of this research was to investigate the effect of two peaks exercise training program during one week on some hepatic stress indexes (AST, ALT) in active girls.
Method: Twelve physical education girl students with ranged between 16-18 years old and mean maximal oxygen consumption 35.2±3.4 ml/kg/min, was selected and divided randomly into an experimental (n=7) and control (n=5) groups. The subjects in the experimental group performed two peaks exercise training program during one week with 70%, 80%, and 90% VO2max intensities in the first three days and repeated in late three days. The control group did not perform any physical activity while the research was underway. Venous blood samples were obtained for analysis before the exercise and the 24 hours after one, 3, 6 days exercise sessions. Data were analyzed by using ANOVA with repeated measure test and independent t-test at significant levels p