Aim: The worldwide obesity epidemic has produced profound effects on public health. The purpose of this study was to examine the effects of aerobic training with orlistat on insulin resistance and lipid profile in obese men.
Method: Forty-eight obese males (Age: 21.56±2.14, Wehght: 103.53±9.44, BMI: 33.9±3.21) participated in this study. The subjects were randomizly divided into four groups: orlistat (O, n=12), exercise (E, n=12), orlistat plus exercise (OE, n=12) and control (C, n=12). Subject in all groups adjusted based on age, height, weight, body mass index and aerobic capacity. Subjects in OE and O groups were consumed three 120 mg orlistat capsules after each meal and for eight weeks. Subjects in OE and E groupps conduct exercise protocol 3 times a week and for 8 weeks. Before and after the exercise program, insulin, glucose, lipid profile, food intake and maximum aerobic power was measured. In statistical analysis, descriptive statistics, paired t-test, one way ANOVA and Tukey post hoc test was used. All data were analyzed using spss and P value less than 0.05 considered statistically significant.
Results: At baseline the results showed that insulin resistance and lipid profile no significant differences between the study groups. Insulin resistance in C group compare to o, e and OE groups was reduced significantly (P<0.01). also, lipid profile was improved significantly except HDl in experimental group.
Conclusion: The results show that regular aerobic exercise without the use of chemical drugs lead to weight loss is desirable changes in insulin resistance and Improvement of lipid profile.