The effect of combined training (aerobic interval and resistive) with two intensity on FGF-21, liver enzymes, insulin resistance and body composition in women with non-alcoholic fatty liver

Mehrabani, Fahimeh; Rahmani Nia, Farhad; Mehrabani, Javad; Razavianzadeh, Nasrin

doi:10.22124/jme.2021.18671.210

Document Type : Research Paper I Open Access I Released under (CC BY-NC) license

Authors

¹ Department of Exercise Physiology, University of Guilan

² University of Guilan

³ Department of Exercise Physiology

⁴ Department of Medical Sciences, Islamic Azad University, Shahrood Branch, Shahrood, Iran

https://doi.org/10.22124/jme.2021.18671.210

Abstract

Introduction: Non-alcoholic fatty liver disease (NAFLD) is a condition in which the accumulation of fat in the liver increases. Exercise training can improve the condition by preventing excessive accumulation of fat in the liver as a non-pharmacological intervention and preventing the progression of the disease to chronic liver disease. The aim of this study was to compare the effect of combined exercises training with two intensities on FGF-21, insulin resistance, liver enzymes and body composition of women with fatty liver.
Materials and Methods: 33 women with NAFLD with a mean age of 57.7 ± 45.43 years and a body mass index of 84.32 6 6 kg/m2 randomly divided into three equal groups; aerobic interval training (AIT); high intensity interval training (HIIT); and controls. The training program was performed for 12 weeks and 3 sessions per week. The variables were measured before and after the training program. Data were analyzed using analysis of variance with repeated measures (p< 0.05).
Results: The results showed that HOMA-IR index and serum FGF-21 were significantly reduced in the combined training groups compared to the control (p<0.05). No significant effect or difference was observed in ALT and AST enzyme levels. Also, a significant decrease in body fat percentage was observed (p<0.05).
Conclusion: It seems that women with NAFLD are likely to be able to use both combined resistance training intensity and moderate to severe interval as a non-pharmacological solution to reduce fat percentage and improve insulin and FGF-21 resistance.

Keywords

20.1001.1.23222867.1400.11.1.3.6

Main Subjects

Exercise Physiology

Publisher: University oF Guilan Copyright © The Authors

This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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The effect of combined training (aerobic interval and resistive) with two intensity on FGF-21, liver enzymes, insulin resistance and body composition in women with non-alcoholic fatty liver

Publisher: University oF Guilan Copyright © The Authors

References

References

Volume 11, Issue 1 - Serial Number 1March 2022Pages 19-35

Volume 11, Issue 1 - Serial Number 1
March 2022
Pages 19-35