Document Type : Research Paper I Open Access I Released under (CC BY-NC) license


1 Department of sport physiology, Ayatollah amoli branch, Islamic Azad University, amol, Iran.

2 Department of sport physiology, Ayatollah amoli branch, Islamic Azad University, amol, Iran

3 Assistant Professor, Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.


Aim: Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) and Adipocyte fatty acid-binding protein (A-FABP) levels of adipose tissue in type 2 diabetic obese rats.
Method: To implementation of this experimental research, 32 obese male wistar rats (weight 320±20 gr) randomly were divided into 4 groups including obese control, shem (obese), obese diabetic, obese diabetic - high-intensity interval training. Intraperitoneal injection of nicotinamide amide-streptozotocin was used to induction type 2 diabetes. high-intensity interval training program was performed 4 days a week for six weeks. VEGF-A and A-FABP levels in rat adipose tissue were measured using by ELISA kit.
Results: the VEGF-A level in adipose tissue in the obese diabetic group was significantly lower than the obese control group (P=0.001). Also, A-FABP (P=0.001) and insulin resistance (P=0.004) was significantly higher in the obese diabetic group than the obese control groups. High-intensity interval training was associated with significant increase of VEGF-A and decrease A-FABP levels in adipose tissue and insulin resistance in obese diabetic rats (P=0.001).
Conclusion: It seems that high-intensity interval training can help improve adipose tissue metabolic parameters and insulin resistance in obese diabetic rats.


Main Subjects



This is an open access article distributed under the following Creative Commons license: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

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Talebi Garkani E, Fathi R, Khodadadi Tirklaei S, Safarzadeh A. The effect of one session of aerobic exercise on the expression of A-FABP gene in visceral adipose tissue of diabetic rats. Iranian Journal of Diabetes and Metabolism 2012; 11 (4): 358-365. [Persian].