The effect of endurance training and chlorogenic acid consumption on oxidative  stress markers in diabetic mices

Ghasemi Pour, Sahar; Marandi, Sayyed Mohammad

doi:10.22124/jme.2023.23408.236

Document Type : Research Paper I Open Access I Released under (CC BY-NC) license

Authors

Department of sport sciences, University of Isfahan, Isfahan, Iran

https://doi.org/10.22124/jme.2023.23408.236

Abstract

Oxidative stress is involved in occurrence and side effects of many diseases .Considering the high prevalence of diabetes in the society and the economic and health consequences caused by it, the present study tries to evaluate the effect of endurance exercise and chlorogenic acid on some pressure indicators.35 4 weeks male C57BL6 mice were randomly assigned to two groups of high-fat diet to induce pre-diabetes and normal diet. After induction of prediabetes,after 12 weeks of high fat diet consumption the samples of this group were divided into groups without intervention, chlorogenic acid consumption, endurance training, endurance training and chlorogenic acid (n=7). The training protocol was performed incrementally . Chlorogenic acid at the rate of 110 mg per kilogram of mouse weight was given to the groups . 24 hours after the last training session and consumption of chlorogenic acid, tissue removal was done from the quadriceps skeletal muscle and after weighing, it was taken to the laboratory to measure GPX, NO, TAC and MDA. One-way ANOVA test at 0.05 level was used to analyze the data. Findings: Endurance training decreased GPX, NO, TAC, and MDA. Chlorogenic acid decreased GPX, NO, and increased TAC and MDA, and their simultaneous intervention increased GPX, TAC, and MDA and decreased NO.According to the findings of this research, it seems that endurance exercise and chlorogenic acid consumption can be used as a non-pharmacological intervention to prevent oxidative stress in the body and its complications. It can also play a preventive role in diabetic patients.

Keywords

Main Subjects

Exercise Physiology

References

Akbarpour M,Aghazadeh J,EEsa nejad A. [The Effect of Intense Training Activity on Gene Expression of Lymphocyte Catalase Enzyme in Soccer Players]. Physiology Of Exercise And Physical Activity Journal 2015; (Persian)
2. Al-Rayahi IAM.[The Role Of Properdin In Tumour Development And Cell Recruitment: University Of Leicester].Phys Rev 2017;47:777-780.
3. Ammar A, Trabelsi K, Boukhris O, Glenn JM, Bott N, Masmoudi L, et al.[Effects of Aerobic-, Anaerobic- and Combined-Based Exercises on Plasma Oxidative Stress Biomarkers in Healthy Untrained Young Adults]. Int J Environ Res Public Health 2020;17(7).
Amralahi Z, Avendi S, Khalidi N. [Effect of Six Weeks of Incremental Resistance Training on Hippocampal BDNF Gene Expression and Serum TNF-α Changes in Male Diabetic Wistar Rats]. Physiology Of Exercise And Physical Activity Journal 2022;15(1):1-10. (Persian)
5. Belenguer-Varea Á, Tarazona-Santabalbina FJ, Avellana-Zaragoza JA, Martínez-Reig M, Mas-Bargues C, Inglés M. [Oxidative stress and exceptional human longevity: Systematic review]. Free Radical Biology and Medicine 2020;149:51-63.
6. Bonita JS, Mandarano M, Shuta D, Vinson J.[Coffee And Cardiovascular Disease: In Vitro, Cellular, Animal, And Human Studies]. Pharmacol Res 2007;55(3):187-98.
Borojni A, Amin, Karfard, Alaei, Hojjatoleh. [Effect of 12 Weeks of Aerobic Training in Polluted Air and Vitamin C Supplementation on Serum Levels of Endothelin-1 and Nitric Oxide in Wistar Rats]. Journal of Isfahan Medical School 2020;38(576):339-46.(persian)
Bulbali, Lotfali, Landi Kh.[Comparison of the Effect of Endurance Training on Glutathione Peroxidase and Superoxide Dismutase Activity of Heart Tissue of Healthy and Diabetic Rats]. Yafte 2020;21(4):20-31.(Persian)
9. Eskandari Z, Mirzaei B, Arazi H.[Comparison Of An Aerobic Training Course With A Herbal Supplementation (Valeriana Wallichii And Melissa Officinalis) Regarding Serotonin Levels, Nitric Oxide And Headache Indices In Women With Migraine]. Daneshvar Medicine 2018;26(2):51-64.
10. Ezeiruaku F, Udenwoke I. [Evaluation Of Plasma Glutathione Peroxidase (GPX) Enzyme In Type 1 And Type 2 Chronic Diabetes Mellitus Patients In Yenegoa, Bayelsa State Of Nigeria].Int Res Med Sci 2016;4(3):050-4.
11. Farahati S, Atarzadeh Hosseini SR, Bijeh N, Mahjoob O. [The Effect Of Aerobic Exercising On Plasma Nitric Oxide Level And Vessel Endothelium Function In Postmenopausal Women]. Razi Journal of Medical Sciences 2014;20(115):78-88.
12. Farhangi N, Nazem F, Zehsaz F. [Effect Of Endurance Exercise On Antioxidant Enzyme Activities And Lipid Peroxidation In The Heart Of The Streptozotocin-Induced Diabetic Rats]. SSU_Journals 2017;24(10):798-809.6.Flack JR, Lee AS. [Prediabetes: preventing progression to diabetes].2015.
Ghorbin, Bahloul, Alamdari A, Karim, Saberi, Shekralehi, et al.[The Effect of a Period of Increasing Endurance Interval Training (Rope Jumping) on Antioxidant Biomarkers and Oxidative Stress in Inactive Girls]. Quarterly journal of Nursing, Midwifery and Paramedicine 2018;4(1):29-40.(persian)
14. Gómez-Martínez S, Díaz-Prieto LE, Castro IV, Jurado C, Iturmendi N, Martín-Ridaura MC, et al. [Moringa Oleifera Leaf Supplementation As A Glycemic Control Strategy In Subjects With Prediabetes]. Nutrients 2021;14(1):57.
15. Hong J-H, Kim M-J, Park M-R, Kwag O-G, Lee I-S, Byun BH, et al.[Effects Of Vitamin E On Oxidative Stress And Membrane Fluidity In Brain Of Streptozotocin-Induced Diabetic Rats]. Clinica Chimica Acta 2004;340(1-2):107-
16. Kawamura T, Muraoka I.[Exercise-Induced Oxidative Stress And The Effects Of Antioxidant Intake From A Physiological Viewpoint]. Antioxidants (Basel) 2018;7(9).
17. Kazeminasab F, Marandi SM, Ghaedi K, Safaeinejad Z, Esfarjani F, Nasr-Esfahani MH. [A Comparative Study On The Effects Of High-Fat Diet And Endurance Training On The PGC-1α-FNDC5/Irisin Pathway In Obese And Nonobese Male C57BL/6 Mice]. Appl Physiol Nutr Metab 2018;43(7):651-62.
18. LOUIS Z, MARTINE NN. [A Participatory Survey And Inventory Of Timber And Non Timber Forest Products Of The Tikar Plain].
19. Matsubara K, Higaki T, Matsubara Y, Nawa A.[Nitric Oxide And Reactive Oxygen Species In The Pathogenesis Of Preeclampsia]. Int J Mol Sci 2015;16(3):4600-14.
20. Matthew Muma D. [Mapping of Studies on Employment Creation of Agriculture and Agro-processing in Kenya Final Report]. 2016.
21. Mehri A.[Effect Of 8 Weeks Aerobic Training And Supplementation Of Resveratrol On Oxidative Marker MDA And Antioxidant SOD And GPX Cardiomyocytes Tissue In Streptozotocin-Diabetic Rats]. 2020.
22. Melega S, Canistro D, De Nicola G, Lazzeri L, Sapone A, Paolini M.[Protective Effect Of Tuscan Black Cabbage Sprout Extract Against Serum Lipid Increase And Perturbations Of Liver Antioxidant And Detoxifying Enzymes In Rats Fed A High-Fat Diet]. British Journal Of Nutrition 2013;110(6):988-97.
23. Mubarak A, Bondonno CP, Liu AH, Considine MJ, Rich L, Mas E, et al. [Acute Effects Of Chlorogenic Acid On Nitric Oxide Status, Endothelial Function, And Blood Pressure In Healthy Volunteers: A Randomized Trial]. Journal Of Agricultural And Food Chemistry 2012;60(36):9130-6.
24. Palau V, Jarrín J, Villanueva S, Benito D, Márquez E, Rodríguez E, et al.[Endothelial ADAM17 Expression in the Progression of Kidney Injury in an Obese Mouse Model of Pre-Diabetes]. International Journal Of Molecular Sciences 2021;23(1):221.
25. Pitocco D, Crino A, Di Stasio E, Manfrini S, Guglielmi C, Spera S, et al.[The Effects Of Calcitriol And Nicotinamide On Residual Pancreatic Β‐Cell Function In Patients With Recent‐Onset Type 1 Diabetes (IMDIAB XI)]. Diabetic Medicine 2006;23(8):920-3.
26. Sepidarkish M, Farsi F, Akbari-Fakhrabadi M, Namazi N, Almasi-Hashiani A, Hagiagha AM, et al. [The Effect Of Vitamin D Supplementation On Oxidative Stress Parameters: A Systematic Review And Meta-Analysis Of Clinical Trials]. Pharmacological Research 2019;139:141-52.
27. Shahidi F, Shakeri C, Delfani Z. [The Effect Of Eight Weeks Interval Aerobic Exercise And Consumption Of Green Tea Supplementation On Oxidative Stress Indices Of Inactive Young Girls]. Razi Journal Of Medical Sciences 2019;25(11):72-84.(persian)
Sudabah S., Hamid R., Pejman M., Mohammadreza D., Mojtabi K.[The Effect of Eight Weeks of Combined Exercise on the Serum Levels of Adropin and Nitric Oxide in Postmenopausal Women with Hypertension]. Physiology and Management Researches in Sports 2018;11(1):129-143.
29. Yu L, Zhai Y, Shen S. [Association between vitamin D and prediabetes: A PRISMA-compliant meta-analysis]. Medicine 2020;99(8).

30. Zhang M, Chen L. [Berberine In Type 2 Diabetes Therapy: A New Perspective For An Old Antidiarrheal Drug?]. Acta Pharmaceutica Sinica B 2012;2(4):379-86

Metabolism and Exercise

The effect of endurance training and chlorogenic acid consumption on oxidative stress markers in diabetic mices

References

References

Volume 12, Issue 2
March 2022

The effect of endurance training and chlorogenic acid consumption on oxidative stress markers in diabetic mices

References

References

Volume 12, Issue 2March 2022

Volume 12, Issue 2
March 2022