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Psycho-physiological effects of high intensity interval training and vitamin E consumption in elderly trimethyltin-treated Alzheimer's rats

Document Type : Research Paper I Open Access I Released under (CC BY-NC) license

Authors

1 Department of Sport Sciences, University of Kurdistan, Sanandaj, Iran

2 Department of Sport Physiology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

Abstract

Introduction: Aging is associated with neurodegenerative and psychological disorders. Considering the ambiguity in the interactive effect of exercise and antioxidants, the aim of this study was to investigate the psycho-physiological effects of high intensity interval training (HIIT) and vitamin E (VE) in elderly trimethyltin (TMT)-treated Alzheimer's rats.
Methods: In this experimental study, 50 Alzheimer's rats (age 18-22 months; weight 280-320 grams) induced by 10 mg/kg TMT were divided into five groups, including: (1) TMT, (2) sham/ vitamin E solvent, (3) VE, (4) HIIT (90-95% of the maximum speed) and (5) HIIT+VE. Ten healthy rats were included in the healthy control (HC) group to investigate the effect of TMT on research variables. HIIT was performed for eight weeks, three sessions per week, and VE was given orally to the rats at a dose of 30 mg/kg.
Results: In the HIIT and HIIT+VE groups, anthropometric indicators, food intake, anxiety and depression were significantly lower, and aerobic capacity, movement balance, and pain tolerance threshold were higher than the TMT group (P≥0.05). In the VE group, visceral fat weight, food intake, anxiety and depression were significantly lower than the TMT group (P≥0.05). Aerobic capacity was significantly higher in HIIT and HIIT+VE groups, and anxiety and depression were significantly lower than in the VE group (P≥0.05).
Conclusion: It seems that HIIT, VE and HIIT + VE improve the weight, BMI and FW and physical and psychological performance, but the effects of HIIT on physical and psychological performance are much stronger than the effect of VE.

Keywords

Main Subjects

References
  1. Gonzales MM, Garbarino VR, Pollet E, Palavicini JP, Kellogg DL, Kraig E, et al. (2022). Biological aging processes underlying cognitive decline and neurodegenerative disease. J Clin Invest. 16;132(10):e158453.
  2. Aza A, Gómez-Vela M, Badia M, Begoña Orgaz M, González-Ortega E, Vicario-Molina I, et al. (2022). Listening to families with a person with neurodegenerative disease talk about their quality of life: integrating quantitative and qualitative approaches. Health Qual Life Outcomes. 20(1):1–12.
  3. Alghadir AH, Gabr SA, Iqbal ZA, Al-Eisa E. (2019). Association of physical activity, vitamin E levels, and total antioxidant capacity with academic performance and executive functions of adolescents. BMC Pediatr.19(1):1–8.
  4. Johansson M, Stomrud E, Johansson PM, Svenningsson A, Palmqvist S, Janelidze S, et al. (2022). Development of Apathy, Anxiety, and Depression in Cognitively Unimpaired Older Adults: Effects of Alzheimer’s Disease Pathology and Cognitive Decline. Biol Psychiatry. 1;92(1):34-43
  5. Stokes AC, Xie W, Lundberg DJ, Hempstead K, Zajacova A, Zimmer Z, et al. Increases in BMI and chronic pain for US adults in midlife, 1992 to 2016. (2020). SSM-Population Heal.;12:100644.
  6. Hosseini SA, Salehi O, Keikhosravi F, Hassanpour G, Ardakani HD, Farkhaie F, et al. (2022). Mental health benefits of exercise and genistein in elderly rats. Exp Aging Res. 48(1):42–57.
  7. Wu C, Yang L, Li Y, Dong Y, Yang B, Tucker LD, et al. (2020). Effects of Exercise Training on Anxious-Depressive-like Behavior in Alzheimer Rat. Med Sci Sports Exerc. 52(7):1456-1469.
  8. Lee G, Kim Y, Jang J-H, Lee C, Yoon J, Ahn N, et al. (2022). Effects of an Exercise Program Combining Aerobic and Resistance Training on Protein Expressions of Neurotrophic Factors in Obese Rats Injected with Beta-Amyloid. Int J Environ Res Public Health.19(13):7921.
  9. Bernardo TC, Beleza J, Rizo-Roca D, Santos-Alves E, Leal C, Martins MJ, et al. (2020). Physical exercise mitigates behavioral impairments in a rat model of sporadic Alzheimer’s disease. Behav Brain Res. 379:112358.
  10. Ramos RM, Coelho-Júnior HJ, Asano RY, Prado RCR, Silveira R, Urtado CB, et al. (2019). Impact of moderate aerobic training on physical capacities of hypertensive obese elderly. Gerontol Geriatr Med. 5:2333721419859691.
  11. Hosseini SA, Salehi OR, Farzanegi P, Farkhaie F, Darvishpour AR, Roozegar S. (2020). Interactive Effects of Endurance Training and Royal Jelly Consumption on Motor Balance and Pain Threshold in Animal Model of the Alzheimer Disease. Arch Neurosci. 7(2):e91857.
  12. Borrega-Mouquinho Y, Sánchez-Gómez J, Fuentes-García JP, Collado-Mateo D, Villafaina S. (2021). Effects of high-intensity interval training and moderate-intensity training on stress, depression, anxiety, and resilience in healthy adults during coronavirus disease 2019 confinement: a randomized controlled trial. Front Psychol. 12:643069.
  13. Batrakoulis A, Fatouros IG. (2022). Psychological Adaptations to High-Intensity Interval Training in Overweight and Obese Adults: A Topical Review. Sports. 22;10(5):64.
  14. Wang W, Li J, Zhang H, Wang X, Zhang X. (2021). Effects of vitamin E supplementation on the risk and progression of AD: a systematic review and meta-analysis. Nutr Neurosci. 24(1):13–22.
  15. Luo J, Hashimoto Y, Martens LG, Meulmeester FL, Ashrafi N, Mook-Kanamori DO, et al. (2022). Associations of metabolomic profiles with circulating vitamin E and urinary vitamin E metabolites in middle-aged individuals. Nutrition. 93:111440.
  16. Ding J, Zhang Y. (2022). Associations of Dietary Vitamin C and E Intake With Depression. A Meta-Analysis of Observational Studies. Front Nutr. 9: 857823.
  17. Alghadir AH, Gabr SA, Anwer S, Li H. (2021). Associations between vitamin E, oxidative stress markers, total homocysteine levels, and physical activity or cognitive capacity in older adults. Sci Rep. 11(1):1–10.
  18. Bacanoiu MV, Danoiu M. (2022). New Strategies to Improve the Quality of Life for Normal Aging versus Pathological Aging. J Clin Med. 11(14):4207.
  19. Robertson DG, Gray RH, De LaIglesia FA. (1987). Quantitative assessment of trimethyltin induced pathology of the hippocampus. Toxicol Pathol. 15(1):7–17.
  20. Chang LW, Wenger GR, McMillan DE, Dyer RS. (1983). Species and strain comparison of acute neurotoxic effects of trimethyltin in mice and rats. Neurobehav Toxicol Teratol. 5(3):337–50.
  21. Gawel K, Gibula E, Marszalek-Grabska M, Filarowska J, Kotlinska JH. (2019). Assessment of spatial learning and memory in the Barnes maze task in rodents—methodological consideration. Naunyn Schmiedebergs Arch Pharmacol. 392(1):1–18.
  22. Vasconcelos-Filho FSL, da Rocha-E-Silva RC, Martins JER, Godinho WDN, da Costa V V, Ribeiro JKC, et al. (2020). Neuroprotector Effect of Daily 8-Minutes of High-Intensity Interval Training in Rat Aβ1-42 Alzheimer Disease Model. Curr Alzheimer Res. 17(14):1320–33.
  23. Hamid NAA, Hasrul MA, Ruzanna RJ, Ibrahim IA, Baruah PS, Mazlan M, et al. (2011). Effect of vitamin E (Tri E®) on antioxidant enzymes and DNA damage in rats following eight weeks exercise. Nutr J. 10(1):1–7.
  24. Nouri H, Sheikholeslami-Vatani D, Moloudi MR. (2021). Changes in UPR-PERK pathway and muscle hypertrophy following resistance training and creatine supplementation in rats. J Physiol Biochem. 77(2):331–9.
  25. Hosseini SA, Norouzi S, Rafiee N, Farzanegi P, Salehi O, Farkhaie F. (2018). Interactive Effects of Endurance Training and Crocin on Aerobic Capacity, Dietary Intake and Weight of High-Fat Diet-Induced Type 2 Diabetic Rats. J Nutr Sci Diet. 4(3):65-74.
  26. Fatemi Tabatabaei SR, Shahriari A, Abaszadeh M. (2014). Effect of vitamin c on the obesity indices of high fat fed diet rats. Jundishapur Sci Med J. 13(1):32–42.
  27. Salehi O, Farkhaie F, Jamali Fashi R, Rakhshanizadeh A. (2022). The Effect of Interval and Continued Trainings with Citrus Aurantium on Pain Threshold and Motor Balance in Elderly Rats. Jorjani Biomed J. 10(2):1–9.
  28. Deuis JR, Dvorakova LS, Vetter I. (2017). Methods used to evaluate pain behaviors in rodents. Front Mol Neurosci. 10:284.
  29. Luo X, Shui Y, Wang F, Yamamoto R, Kato N. (2017). Impaired retention of depression-like behavior in a mouse model of Alzheimer’s disease. IBRO reports. 2:81–6.
  30. Walf AA, Frye CA. (2007). The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2(2):322–8.
  31. Dantas EM, Pimentel EB, Gonçalves CP, Lunz W, Rodrigues SL, Mill JG. (2010). Effects of chronic treadmill training on body mass gain and visceral fat accumulation in overfed rats. Brazilian J Med Biol Res. 43:515–21.
  32. Pieczyńska A, Zasadzka E, Trzmiel T, Pyda M, Pawlaczyk M. (2021). The effect of a mixed circuit of aerobic and resistance training on body composition in older adults—retrospective study. Int J Environ Res Public Health. 18(11):5608.
  33. Frimel TN, Sinacore DR, Villareal DT. (2008). Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults. Med Sci Sports Exerc. 40(7):1213.
  34. Thomas E, Gentile A, Lakicevic N, Moro T, Bellafiore M, Paoli A, et al. (2021). The effect of resistance training programs on lean body mass in postmenopausal and elderly women: A meta-analysis of observational studies. Aging Clin Exp Res. 33(11):2941–52.
  35. Otsuka Y, Iidaka T, Horii C, Muraki S, Oka H, Nakamura K, et al. (2021). Dietary intake of vitamin E and fats associated with sarcopenia in community-dwelling older Japanese people: a cross-sectional study from the fifth survey of the ROAD study. Nutrients. 13(5):1730.

 

  1. Khor SC, Abdul Karim N, Wan Ngah WZ, Mohd Yusof YA, Makpol S. (2014). Vitamin E in sarcopenia: current evidences on its role in prevention and treatment. Oxid Med Cell Longev. 2014:914853.
  2. Shen X-H, Tang Q-Y, Huang J, Cai W. (2010). Vitamin E regulates adipocytokine expression in a rat model of dietary-induced obesity. Exp Biol Med. 235(1):47–51.
  3. Mulligan AA, Lentjes MAH, Luben RN, Khaw KT, Welch AA. (2016). Dietary vitamin E intake is associated with greater fat-free mass and percentage fat-free mass in the EPIC-Norfolk cohort. Proc Nutr Soc. 75(E182).
  4. Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, et al. (2005). Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab. 90(11):5970–7.
  5. Ahmed AF. (2011). Effect of sensorimotor training on balance in elderly patients with knee osteoarthritis. J Adv Res. 2(4):305–11.
  6. Seghatoleslami A, Hemmati Afif A, Irandoust K, Taheri M. (2018). Effect of Pilates Exercises on Motor Performance and Low Back Pain in Elderly Women With Abdominal Obesity. 1;13(3):396–404.
  7. Tse MMY, Tang SK, Wan VTC, Vong SKS. (2014). The effectiveness of physical exercise training in pain, mobility, and psychological well-being of older persons living in nursing homes. Pain Manag Nurs  Off J Am Soc Pain  Manag Nurses. 15(4):778–88.
  8. Kalapotharakos VI. (2007). Aerobic exercise in older adults: effects on VO 2 max and functional performance. Crit Rev Phys Rehabil Med. 9(3):213-226.
  9. Kim M, Eo H, Lim JG, Lim H, Lim Y. (2022). Can Low-Dose of Dietary Vitamin E Supplementation Reduce Exercise-Induced Muscle Damage and Oxidative Stress? A Meta-Analysis of Randomized Controlled Trials. Nutrients. 14(8):1599.
  10. Jessup J V, Horne C, Yarandi H, Quindry J. (2003). The effects of endurance exercise and vitamin E on oxidative stress in the elderly. Biol Res Nurs. 5(1):47–55.
  11. Abd El-Kader SM, Al-Jiffri OH. (2016). Aerobic exercise improves quality of life, psychological well-being and systemic inflammation in subjects with Alzheimer’s disease. Afr Health Sci. 16(4):1045–55.
  12. Williams CL, Tappen RM. (2008). Exercise training for depressed older adults with Alzheimer’s disease. Aging Ment Heal. 12(1):72–80.
  13. Farina N, Llewellyn D, Isaac MGEKN, Tabet N. (2017). Vitamin E for Alzheimer’s dementia and mild cognitive impairment. Cochrane database Syst Rev. 18;4(4):CD002854.
  14. Morris MC, Evans DA, Bienias JL, Tangney CC, Wilson RS. (2002). Vitamin E and cognitive decline in older persons. Arch Neurol. 59(7):1125–32.

50.   Browne D, McGuinness B, Woodside J V, McKay GJ. (2019). Vitamin E and Alzheimer’s disease: what do we know so far? Clin Interv Aging. 14:1303.

Metabolism and Exercise
Volume 11, Issue 2 - Serial Number 2
September 2022
Pages 57-76
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History
  • Receive Date: 26 February 2023
  • Revise Date: 03 March 2023
  • Accept Date: 12 March 2023
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