Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
- Mehdi Pahlevani 1
- Jabbar Bashiri 2
- Roghayeh Pouzesh Jadidi 3
- Rasoul Hashem Kandi Asadi 4
- Masoomeh Dadkhah 5
1 Phd Student of Sports Physiology, Department of Sports Physiology, Faculty of Human Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
2 Professor Associate of Sports Physiology, Department of Sports Physiology, Faculty of Human Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
3 Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran
4 3. Assistant Professor of Exercise Physiology, Department of Exercise Physiology, Faculty of Human Sciences, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
5 Assistant Professor, Pharmaceutical Sciences Research Center, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran.
Abstract
Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.
After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.
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Main Subjects
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