Document Type : Research Paper I Open Access I Released under (CC BY-NC) license

Authors

1 Assistant Professor

2 Associate Professor

Abstract

Aim: physical activity can play a supportive role in breast cancer improvement by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory cytokine that plays an important role in preventing the growth and metastasis of breast cancer, and interleukin 4 is an inflammatory cytokine that causes the growth and development of cancer cells. The present study was conducted with the aim of investigating the effect of 12 weeks of Pilates exercises on the serum levels of interleukin 4 and interleukin 10 in women with breast cancer.
Method: The present study was conducted in a semi-experimental manner with two experimental and control groups on 30 women with breast cancer. The experimental group was given Pilates exercises for 12 weeks and 3 sessions each week for 60 minutes, while the control group did not participate in any physical activity. Blood samples were taken 48 hours before and after exercise intervention to measure interleukin 4 and 10 variables.
Results: Based on the results of the correlated t test, the serum level of interleukin 10 in the experimental group increased significantly compared to the control group (P=0.001), and the amount of interleukin 4 in the experimental group showed a significant decrease compared to the control group(P=0.001).
Conclusion: Performing Pilates exercises with the benefit of anti-inflammatory cytokines and reducing inflammatory cytokines improves the health status of women with breast cancer. Therefore, doing exercises can help patients as a therapeutic factor.
Keywords: interleukin 10, interleukin 4, Pilates exercises, breast cancer

Keywords

Main Subjects

  1. 1. Mahmodieh B, Alizadeh M.H, Akochekian M, H. E. Investigating the effect of 6 weeks of resistance training with stretch on the isometric strength of limb muscles Upper and lower of women with breast cancer. Applied sports physiology research paper. 2017;3(26):153-160.
  2. 2. Farsani MG, Reiisi S, Peymani M. Study of down regulation of IL-37 expression in breast cancer tumoral tissues and its association with grade 3 tumor. Scientific Journal of Kurdistan University of Medical Sciences. 2018;23(4):67-76.
  3. 3. Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. IL-37 is a fundamental inhibitor of innate immunity. Nature immunology. 2010;11(11):1014-22.
  4. 4. Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. International journal of cancer. 2019;144(8):1941-53.
  5. 5. Delfan M, Rasekh Nejad Z, Delphan M. Synergistic Effect of Endurance Training Combined with Curcumin on Intratumoral Expression of Interleukin-4 (Il4) and Stat-6 in Female Mice with Breast Cancer. Iranian Journal of Breast Diseases. 2020;13(3):52-61.
  6. 6. Amal SH. Association of Breast Cancer and In situ expression of Interleukin-4 (IL-4) and IL-10. Al Mustansiriyah Journal of Pharmaceutical Sciences. 2010;8(2):22-32.
  7. 7. Zhang WJ, Li BH, Yang XZ, Li PD, Yuan Q, Liu XH, et al. IL-4-induced Stat6 activities affect apoptosis and gene expression in breast cancer cells. Cytokine. 2008;42(1):39-47.
  8. 8. Ghorbanian B, MONTAZERI V, Rostami F, Khanvari T. Effect of combined exercises (aerobic-pilates) on the serum level of interleukin 10 and blood platelets in women with breast cancer. 2021;24(1):9-17.
  9. 9. Carpi A, Nicolini A, Antonelli A, Ferrari P, Rossi G. Cytokines in the management of high risk or advanced breast cancer: an update and expectation. Current Cancer Drug Targets. 2009;9(8):888-903.
  10. 10. Apryani E, Ali U, Wang Z-Y, Wu H-Y, Mao X-F, Ahmad KA, et al. The spinal microglial IL-10/β-endorphin pathway accounts for cinobufagin-induced mechanical antiallodynia in bone cancer pain following activation of α7-nicotinic acetylcholine receptors. Journal of neuroinflammation. 2020;17(4):1-18.
  11. 11. Mocellin S, Marincola FM, Young HA. Interleukin‐10 and the immune response against cancer: a counterpoint. Journal of leukocyte biology. 2005;78(5):1043-51.
  12. 12. Kushi LH, Byers T, Doyle C, Bandera EV, McCullough M, Gansler T, et al. American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA: a cancer journal for clinicians. 2006;56(5):254-81.
  13. 13. Li Y, Zhao M, Guo C, Chu H, Li W, Chen X, et al. Intracellular mature IL-37 suppresses tumor metastasis via inhibiting Rac1 activation. Oncogene. 2011;38(8):106-115.
  14. 14. Shahar S, Salleh RM, Ghazali AR, Koon PB, Mohamud W. Roles of adiposity, lifetime physical activity and serum adiponectin in occurrence of breast cancer among Malaysian women in Klang Valley. Asian Pac J Cancer Prev. 2010;11(1):61-76.
  15. 15. Jones LW, Viglianti BL, Tashjian JA, Kothadia SM, Keir ST, Freedland SJ, et al. Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. Journal of applied physiology. 2010;108(2):343-358.
  16. 16. Murphy EA, Davis JM, Barrilleaux T, McClellan J, Steiner J, Carmichael M, et al. Benefits of exercise training on breast cancer progression and inflammation in C3 (1) SV40Tag mice. Cytokine. 2011;55(2):274-9.
  17. 17. Shen Y, Han Z, Liu S, Jiao Y, Li Y, Yuan H. RETRACTED ARTICLE: Curcumin Inhibits the Tumorigenesis of Breast Cancer by Blocking Tafazzin/Yes-Associated Protein Axis. Cancer Management and Research. 2020:14(93):495-502.
  18. 18. Babaei Bonab S. The Effect of 12 Weeks of Pilates Training and Ginger Consumption on Serum Levels of BDNF and TNF-α in Women with Multiple Sclerosis. Journal of Ardabil University of Medical Sciences. 2020;20(3):307-317.
  19. 19. Alizadeh AM, Sadeghizadeh M, Najafi F, Ardestani SK, Erfani-Moghadam V, Khaniki M, et al. Encapsulation of curcumin in diblock copolymer micelles for cancer therapy. BioMed research international. 2015;2015.
  20. 20. Abdalla DR, Murta EF, Michelin MA. The influence of physical activity on the profile of immune response cells and cytokine synthesis in mice with experimental breast tumors induced by 7, 12-dimethylbenzanthracene. European journal of cancer prevention. 2013;22(3):251-258.
  21. 21. Delphan M, Agha Alinejad H, Delfan M, Dehghan S. Intratumoral effects of continuous endurance training and high intensity interval training on genes expression of miR-21 and bcl-2 in breast cancer bearing female mice. Iranian Journal of Breast Diseases. 2017;10(2):49-57.
  22. 22. Zubiaga A, Munoz E, Huber BT. IL-4 and IL-2 selectively rescue Th cell subsets from glucocorticoid-induced apoptosis. Journal of immunology (Baltimore, Md: 1950). 1992;149(1):107-112.
  23. 23. Shahidi Rad M, Askari R, Hosseini Kakhk SA. The Effect of resistance training on changes in some cytokines and muscle strength in women with multiple sclerosis. Journal of Sport Biosciences. 2020;11(4):365-377.
  24. 24. Donatto FF, Neves RXd, Rosa FdO, Camargo R, Ribeiro H, Matos-Neto EMd, et al. Resistance exercise modulates lipid plasma profile and cytokine content in the adipose tissue of tumour-bearing rats. Cytokine. 2013;61(2):426-32.
  25. 25. Kizaki T, Takemasa T, Sakurai T, Izawa T, Hanawa T, Kamiya S, et al. Adaptation of macrophages to exercise training improves innate immunity. Biochemical and biophysical research communications. 2008;372(1):152-6.

26.          Vear NK, Coombes JS, Bailey TG, Skinner TL. The interplay between vascular function and sexual health in prostate cancer: the potential benefits of exercise training. Medical Sciences. 2020;8(1):11-17