AbstractAim: The purpose of this study was to determine the effects of two ergogenic drinks on metabolic indices changes in soccer players.Method: Forty eight soccer players (24 women and 24 men) with mean age of 18.7 ± 4.7 years were selected as two groups, long-term and short-term intermittent exercise. Then, each group randomly was divided into three; Zamzam (SD), Isostar (ID) and placebo (P) groups. Long-term intermittent exercise includes six stages of exercise in two half time. Fifteen minutes after breakfast, players have drunk 6 ml/kg of beverage and 1 ml/kg at the end of stages 1, 2, 4, and 5. In addition, they drank 4 ml/kg at the end of third stage (1st half time). Before and immediately after long-term intermittent exercise, blood glucose, insulin and triglyceride levels were measured. Blood lactate was measured at rest, 3 minutes after the first and second half time. Short-term intermittent exercise, includes three complete stages of RAST test with 10 minutes rest. Fifteen minutes after breakfast and at the end of each stage 2 ml/kg beverage were drunk. Glucose and blood lactate levels were measured at rest and immediately after each stage of RAST test. Results: Results showed that a significant increase in insulin and blood glucose levels after long-term activity in SD and ID groups. In addition, there was a significant increase in blood glucose levels at 3 minutes after every stage of the RAST test in SD and ID groups. However, in any variables, no significant difference was observed between ID and SD groups.Conclusion: It seems that the use of Zamzam and Isostar relatively the same rate increase level of blood glucose and insulin after long-term high- intensity intermittent exercise. Therefore, we can recommend to athletes to consume synergy beverage of Zamzam which is produce in own country.Key words: Ergogenic beverage, Zamzam, Isostar, Ekblom test, Rast test