Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Author
University faculty member
Abstract
Objective: Aerobic training and Saffron has decreasing effects on apoptosis induced by exercise to exhaustion. The present study aims to investigate the Interactive effect of aerobic training with Saffron extract on BAX and Bcl2 proteins of cardiac tissue in trained rats following an aerobic exercise until exhaustion. Methods: This is a clinical trial, 48 Wistar male rats were assigned into following four groups (N=12): control )C) , Saffron extract) SE) , Aerobic training (AT) , Aerobic training + Saffron extract (AT+SE). Aerobic training was done for five times a week for 8 weeks. Saffron extract was administrated through oral gavage 100 mg.kg-1.day-1. The end of experiment, half of the rats was killed immediately before exhaustive training; on the other hand, remaining rats were killed immediately after performing an acute bout of exhaustive exercise on the treadmill. BAX and Bcl2 proteins levels were measured by ELISA method. The data were analyzed using a one-way ANOVA, with the significance level of P < 0.05. Results: following an exhausting BAX and Bcl2 proteins of cardiac tissue in the all groups Except in the AT+SE group were significantly increased and decreased respectively (P < 0.05). Conclusion: It seems that aerobic training and use of saffron extract Each one alone or in combination with each other prevented the significant change of Bax and Bcl2 proteins and BAX/Bcl-2 ratio following an exhausting exercise.
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