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Abstract
Abstract
Aim: Endothelial dysfunction is considered an important event in atherosclerosis improvement. On the other hand, diabetes is also associated with endothelial dysfunction. Among the endothelial dysfunction factors, vascular cell adhesion molecule can be mentioned. The purpose of this study was the effect of aerobic exercise on VCAM-1 and insulin resistance index in type 2 diabetes women.
Method: Sixteen women suffering type 2 diabetes (aged: 50.81±7.87, weight: 75.82±15.27 kg) were randomly divided in aerobic (n=11) and control (n=5) groups. The aerobic group exercised for 8 weeks in 45-60 min sessions 3 time a week with 60% HRR. Blood samples were obtained after 10-12 overnight fasting for measuring VCAM-1 serum and insulin levels at pre-and post-exercise training. Statistical analysis was done by independent t-tests and Pearson correlation coefficient.
Results: The results showed a significant difference between aerobic and control groups in VCAM-1 serum levels (P<0.05). Also there exists a relationship between VCAM-1 serum levels with insulin resistance following aerobic exercises (r=0.729).
Conclusion: Eight weeks aerobic exercises can probably cause decreasing of vascular cell adhesion molecules and this decrease has a direct relation with insulin resistance. Decreasing of insulin resistance along with decreasing of adhesive molecules can probably decrease cardiovascular diseases in people with type 2 diabetes.
Key words: Aerobic exercise, Vascular cell adhesion molecule, Insulin resistance index
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