Authors
Abstract
Abstract
Aim: Diabetes mellitus is a metabolic syndrome which is determined by insulin deficiency-induced hyperglycemic or decrease of in body insulin sensitivity. Chronic inflammation conditions in diabetes are associated with Cyclooxigenase 2 enzyme (COX-2) expression. The major metabolites of this enzyme, which play an important role in cardiovascular homeostasis are Prostocyclin (PGI-2) and Tromboxane (TXA-2). However, Prostocyclin is a potent vasodilator and prevents platelet aggregation and Tromboxane causes vasoconstriction, proliferation of smooth muscles and aggregation and remodeling of platelets. The present study investigates the effect of 8 weeks of resistance training on the expression of COX-2 enzyme and its metabolites such as TXA-2 and PGI-2 in wistar diabetic male rats.
Method: For this purpose, in an experimental study 24 wistar rats were purchased from Pasteur Institute of Iran and divided into resistance training (n=12) and control (n=12) groups. The resistance training protocol included 8 weeks (3 sessions per weeks) of ten sets of ladder ascending with free weights were attached to the rats’ tails (70 to 75% of maximum capacity of carrying free weights by each rat).The animals were sacrificed 48 hours after the last session of training program and blood samples were taken. After the left ventricle was drained, stimulatory and inhibitory factors were measured and the data was analyzed by t-test via spss16 software.
Results: The results of independent t-test showed that there was a significant decrease in blood glucose (P<0.05); however, there was no significant difference in insulin levels among groups. In addition, t-test showed that resistance training did not induce any significant difference in TXA-2 and PGI-2 of training group in comparison with control group. In addition, COX-2 level in resistance training group (296.09±41.69) showed a significant increase compared with control group (252.8±26.8), (P<0.05).
Conclusion: The results of the study show that 8 weeks of resistance training does not have any significant impact on stimulatory and inhibitory factors of coronary artery injuries. It appears that the mentioned protocol does not have a significant effect on cardiac microvascular injuries. Due to the lack of information in this area, further study is unavoidable.
Key words: Cyclooxigenase 2 enzyme, Tromboxane 2, Prostocyclin 2, Blood
glucose, Resistance training
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