Aim:Menopause is associated with an imbalance in the expression of atherogenesis genes in the motor nerve terminal. However, the effect of resistance training on the gene expression affecting the inhibition of sarcopenia in the neurotransmitter plate is not well understood.The purpose of this study was to determine the effect of 8 weeks of increasing resistance training on the gene expression of AKT and mTORC-1 in the motor end plate of the quadriceps muscle of post-menopausal wistar rat.
Methods:In this experimental study, 20 female Wistar rats (8 to 12 weeks old) with an average weight of 235 to 265 g, were randomly divided into 2 groups including Resistance Training (RT) and Control (C).Ovariectomy was performed after anesthesia with an intraperitoneal injection of Ketamine/Xylazine mixture with a bilateral incision in the lumbar region. incremental resistance training was performed for 8 weeks, 5 days a week on an 85 degree incline ladder. After 24 hours of the last training session and afterward recovery, animals were sacrificed and their quadriceps muscle was extracted. Real-time PCR was used to determine the expression of AKT and mTORC-1 genes.T-test was used at alpha level of 0.05 to compare the independent groups.
Results:Genes expression AKT and Mtorc-1 were increased in the training group compared to the control(P=0.001 and P=0.003 respectively).The rats body weight did not show significant change in any of the groups(P=0.151).
Conclusion:It seems that increasing resistance training reduces sarcopenia by increasing the genes expression of AKT and mTORC-1 in the motor end plate.