Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Department of exercise physiology, Shiraz branch, Islamic Azad University, Shiraz, Iran
2 Department of biology, Shiraz branch, Islamic Azad University, Shiraz, Iran
Abstract
Aim: The aim of present study was to examine the effect of effect of high intensity interval swimming on Nurr1 and mir-132 gene expression in rats with Parkinson's disease (PD).
Methods: In this experimental study, twenty-one male Wistar rats (weight 200 ± 10.5 grams) were selected. In fourteen rats, PD induced by injection of 1 mg/kg reserpine. Then, these rats were divided into PD group or training group randomly. Seven remaining rats were included in the healthy control group. The rats in the training group, performed high intensity interval swimming, including 20 times of 30 seconds of swimming with 30 seconds of rest between each time for 6 weeks. Hippocampal Nurr1 and mir-132 gene expression were measured 48h after the last session of training. Data were analyzed using one-way ANOVA and LSD post hoc test were run using SPSS-22 at the P <0.05.
Results: The study results indicated that Nurr1 gene expression was lower in the PD group compare to the healthy group and training group (p=0.02 and p=0.02 respectively); while, no significant difference was observed between training group and healthy group (p=0.9). mir-132 gene expression was higher in the PD group compare to the healthy group (p=0.009); while, no significant difference was observed between PD group and training group (p=0.1) and between training group and healthy group (p=0.1).
Conclusion: In summary, it seems that swimming training utilized in this study improves dopaminergic neurons survival and effective for PD.
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