Document Type : Review Article I Open Access I Released under (CC BY-NC) license
Authors
1 Associate Professor of Exercise Physiology, Azarbaijan Shahid Madani University, Tabriz, Iran
2 Assistance professor, Department of Sport Sciences, Faculty of humanities, Hormozgan University, Bandar Abbas, Iran
3 Associate Professor, Sport Sciences Research Institute, Tehran, Iran
Abstract
Background and Aim: Many diseases cause skeletal muscle microvascular rarefaction (MR) and the quantitative determination of the effect size (ES) of exercise training on skeletal muscle capillary to fiber ratio (C/F) can be useful in refining exercise prescriptions for susceptible population. The aim of the present study was to determine the average ES of exercise training on skeletal muscle C/f in patients disposed to MR.
Materials and Methods: A search for English articles was conducted in Web of Science, Scopus, and PubMed databases without limiting the year of publication until February 2023. Weighted mean difference (WMD) with 95% confidence intervals was calculated using random effect model. Correlation between variables was investigated using fixed effects model meta-regression.
Results: A summary ES achieved as WMD=0.21 (95% CI: 0.17 to 0.26) from the results of 308 subjects, included in 22 exercise training interventions (p=0.014, I2=44.16). No correlations were observed in between the changes in C/F and the age of subjects included in each intervention based on action of the moment’s meta-regression model (r=-0.00, p=0.92, z=0.099). Among the exercise duration categories, interventions less than 8 weeks (n=3) had the least ES on C/F (WMD=0.18), while a WMD of 0.22 were determined for both of interventions with 8 weeks (n=7) and more than 8 weeks duration (n=12) categories (z=9.68, p=0.001). Moreover, interventions in HIIT and intensive aerobic exercise training category had greater ES (WMD=0.23) compared to MICT and aerobic exercise training (WMD= 020) interventions (z=9.73, p=0.001).
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