Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
- Fariba Pourasghar 1
- jabbar bashiri 2
- Roghayeh Pouzesh Jadidi 3
- HASSAN POURRAZI 4
- Mir Alireza Nourazar 5
1 PhD student
2 Associate Professor, Department of Physical Education and Sport Science, Islamic Azad University of Tabriz, Iran
3 : Assistant Prof., Department of Exercise Physiology, Tabriz branch, Islamic Azad University, Tabriz, Iran
4 Assistant Professor of Exercise Physiology, Department of Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran
5 Assistant Professor, Department of Veterinary Medicine, Tabriz Azad University of Medical Sciences, Iran.
Abstract
Aim: The aim of the present study is to investigate the effect of intense interval exercise training and melatonin supplementation on the apoptotic indices of kidney tissue in rats suffering from renal ischemia reperfusion injury.
Methods: 30 male Wistar rats (weight: 250 and 300 grams) were randomly divided into 5 groups, healthy, Ischemia/Reperfusion (I/R), I/R + intense interval training, I/R + melatonin supplement and I/R + high intensive interval training + melatonin supplement. Except for the healthy group, the animals were subjected to ischemia-reperfusion in other test groups. The high intensive interval training protocol was implemented for 12 weeks (5 days per week). Caspase 3, BAX, BCL2 and TNFα gene expression indices were measured by real time PCR method. Because of the non-normal distribution of parameters, the data were analysed by Kruskal–Wallis, Mann–Whitney and Wilcoxon test at the significance level of p
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