Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Associate Professor in Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
2 Assisstant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran
3 Ph.D student, Exercise physiology, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tabriz, Tabriz, Iran
4 Master in Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tabriz, Tabriz, Iran
Abstract
Introduction: This research aimed to investigate aerobic training with Vaccinium arctostaphylos L. fruit hydro-alcoholic extract on Oxidative stress and antioxidant defense system in the heart tissue of healthy male rats. Methodology: 24 male Wistar rats (average weight 200 grams) and average age (8 weeks old) were randomly divided into four groups: 1- healthy control, 2- supplementation, 3- aerobic training and 4- supplementation and aerobic training. The rats in the supplement groups received 250 mg of Qaraqat fruit extract per kilogram of body weight daily in the form of oral gavage. The Aerobic training protocol included running on a treadmill at a speed of 5-10 meters per minute for 30-60 minutes, five days a week, observing the overload principle. The levels of MDA, TAC, GPX, and SOD in heart tissue were measured. one-way analysis of variance and Tukey's post hoc tests were used at a significance level of P<0.05. Results: In SOD, there is a significant difference between the control group and the supplement+training group (P=0.044), and in TAC, there is a significant difference between the supplement group and the training group and the training+supplement group (P<0.05). Also, there was a non-significant difference in GPx among the groups, and a significant difference in MDA between the control group and the supplement group and the training+supplement group, and the exercise group and the training+supplement group (P<0.05). Conclusion: Qaraqat supplementation could significantly increase total antioxidant capacity and superoxide dismutase and decrease malondialdehyde. Regular aerobic training improved the antioxidant defense system in healthy mice.
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