Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Ph.D in Exercise Physiology, University Campus2, University of Guilan, Rasht, Iran
2 Department of Exercise Physiology
3 Department of Exercise Physiology, University of Guilan, Rasht, Iran
Abstract
Introduction and purpose: The effect of exercise training on supplying the energy needs of muscle tissues is one of the important questions in training adaptation. Along with exercise, taking some nutrition supplements can improve cellular function. Combining supplements together with concurrent training is a new considerable approach. Therefore, the aim of the present study was to determine the effect of aerobic-resistance trainings and mixed supplementation (L-arginine/caffeine/L-carnitine) on angiogenic factors and hypoxia-inducible factor 1 (VEGF and HIF-1a) in inactive obese men.
Methods: 28 inactive obese men (age 37.02±3.89, height 1.74±0.66 and BMI 34.04±1.24) were randomly were divided into three groups of aerobic-resistance training/combined supplementation (n: 10), aerobic-resistance training/placebo (n: 9) and combined supplement/detraining (n: 9). Aerobic (30 min 55-75% HRmax), resistance trainings (40-45 min/50-70% 1-RM) and a mixed supplement were including 1000 mg of L-arginine, 200 mg of caffeine and 1000 mg of L-carnitine that were performed during 10 weeks (3 session a week).
Findings: The results of the MANCOVA test showed that the aerobic-resistance exercises training with moderate intensity in intraction with the mixed supplement (L-arginine/caffeine/L-carnitine) significantly increased the blood levels of angiogenesis indicators including VEGF (p=0.001) and significantly decreased the levels of HIF1-a (p=0.0001) in inactive obese men.
Conclusion: In summary, the results of the present study showed that the aerobic-resistance training with moderate intensity in intraction with the mixed supplement (L-arginine/caffeine/L-carnitine) were increased angiogenic and hypoxi istimulation factors in inactive obese men.
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