Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Assistant Professor of Exercise Physiology, Faculty of Sport Sciences, Maragheh University, Maragheh, Iran
2 Associate Professor, Faculty of Sport Sciences, University of Maragheh, Maragheh, Iran
Abstract
Introduction: Inflammatory factors are known as an important mechanism in the development of type 2 diabetes and metabolic diseases; while regular exercise training has anti-inflammatory effects and suppresses low-grade systemic inflammation in type 2 diabetes. Therefore, the present study aimed to investigate the effect of combined functional training with Ganoderma supplementation on serum levels of SPRF5, WNT5A and glycemic indices in women with type 2 diabetes.
Materials and Methods: 60 women with type 2 diabetes voluntarily participated in the study and were randomly assigned to four groups: combined functional training group, supplement group, exercise + supplement group, and control group. Subjects in the exercise group performed selected exercise for 12 weeks, three sessions per week. supplement was also consumed daily in the form of tea, 3 grams. Serum fasting blood glucose levels, insulin resistance index, and serum SFRP5 and WNT5A levels were measured.
Results: The results of the analysis of variance test showed that there was a significant difference between the effects of different interventions on serum levels of SFRP5 and WNT5A, blood glucose levels and insulin resistance (p<0.05). Combined functional training combined with supplementation resulted in a decrease in serum levels of WNT5A and an increase in serum levels of SPRF5 in the exercise, supplement, and exercise + supplement groups (p<0.001).
Conclusion: Both intervention methods of combined functional training and supplementation are effective methods in controlling blood sugar and reducing inflammation, and the combination of these two methods is more effective in glycemic control in diabetic patients.
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