Document Type : Review Article I Open Access I Released under (CC BY-NC) license
Authors
1 MSc in Exercise Physiology, Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran.
2 Department of Physical Education and Sport Science, School of Humanities, University of Yasouj, Yasouj, Iran.
3 Professor, Department of Sports Sciences, University of Birjand, Birjand, Iran.
Abstract
Introduction: Diabetes is associated with many pathological changes, and liver damage is one of the most important consequences of diabetes. The aim of the present study was to investigate the effect of aerobic exercise on liver enzymes and insulin resistance in people with type 2 diabetes.
Methods: A systematic search of English and Persian published articles was conducted from PubMed, Web of Science, Scopus, Magiran, Irandon, Noor Mags, and Sid (14 January 2025). To determine the effect size, the mean difference WMD and 95% were calculated using a random effects model. Heterogeneity was assessed using the I2 test and publication bias was assessed using visual analysis of funnel plots and Egger's test.
Findings: A total of 17 studies (with 18 aerobic exercise interventions) and 564 subjects with T2D were meta-analyzed, and the results showed that aerobic exercise intervention in people with T2D was associated with a significant reduction in ALT [WMD= -7.150 Iu/l (-2.519 to -11.781), P=0.002], AST [WMD= -4.005 Iu/l (-1.550 to -6.461), P=0.001] and HOMA [WMD= -0.638, (-0.113 to -1.163), P=0.017] compared to the control group. However, aerobic exercise resulted in a non-significant change GGT [WMD= -5.157 Iu/l (-1.362 to -8.952), P=0.008] Came along.
Conclusions: In summary, aerobic exercise can be considered an efficient strategy in reducing ATT, AST, GGT, and HOMA in people with T2D, and it is recommended to use this method to improve ATT, AST, GGT, and HOMA.
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