Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
Department of Physical Education, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
Abstract
Introduction: Obesity and overweight are major global public health concerns. Obesity-related diabetes leads to mitochondrial dysfunction in adipocytes and promotes inflammation. The present study aimed to investigate the effect of interval training on the expression levels of Humanin and MOTS-c genes in obese diabetic mice.
Methodology: Thirty-two C57BL/6 mice with a mean weight and standard deviation of 20.7 ± 1 g were selected. After consuming a high-calorie diet and becoming obese (mean weight and standard deviation of 30.95 ± 3.20 g), they were divided into three groups: control, diabetic and interval training. Diabetes was induced via intraperitoneal administration of streptozotocin (STZ) for eight weeks. The interval training protocol consisted of 30 minutes of exercise, with intensity progressively increasing from 50% to 60% during low-intensity intervals and 85% to 90% during high-intensity intervals. One-way analysis of variance (ANOVA) and Tukey's post hoc test were used to evaluate the data.
Results: The results indicated that Humanin and MOTS-c gene expression levels in the interval training group significantly decreased compared to the control group and significantly increased compared to the diabetic group (P ≤ 0.001).
Conclusions: In the context of obesity-related diabetes, interval training likely mitigates obesity-related inflammatory and detrimental factors in adipose tissue by enhancing the expression of Humanin and MOTS-c genes.
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