Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran
2 Department of Exercise Physiology, Faculty of Sports Sciences, University of Mazandaran, Babolsar, Iran Athletic Performance and Health Research Center, University of Mazandaran, Babolsar, Iran
Abstract
Background and Purpose: Hepatokines are key regulators of metabolism, and the angiopoietin-like protein 4 (ANGPTL4) plays an important role in lipid metabolism. This study aimed to compare the effects of progressive and constant-load resistance training on hepatic and serum ANGPTL4 levels in sucrose-fed rats.
Methods: Thirty-two male Wistar rats (6–8 weeks old) were randomly assigned to four groups: healthy control, sucrose control, progressive resistance training + sucrose, and constant-load resistance training + sucrose. After 8 weeks of feeding with 10% sucrose solution, training protocols (3 sessions per week, for 8 weeks) was implemented, including climbing a ladder with a weight attached to the tail. ANGPTL4 levels in serum and liver, and serum cholesterol and triglyceride levels were measured.
Results: Tissue concentrations of ANGPTL4 were significantly higher in the progressive resistance training group than in the sucrose control (P=0.003) and constant-load training (P=0.01) groups. More but non-significant weight gain (P=0.057) was observed in the sugar control group compared to the sucrose control group. Serum triglyceride levels were higher in the nutritional intervention groups than in the healthy control group (P<0.001). Serum cholesterol levels were significantly lower in the constant-load training groups compared to the sucrose control (P=0.048).
Conclusions: The significant increase in hepatic ANGPTL4 due to progressive resistance training indicates the importance of training intensity on changes in this hepatokine. This training protocol may also be effective in preventing weight gain caused by excessive sucrose consumption.
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