Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran
Abstract
Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disease affecting more than 50 million people worldwide. The aim of the present study was to determine the effect of aerobic exercise and resveratrol on hippocampal mitochondrial fusion in rats with Alzheimer's disease.
Methods: To conduct the present experimental and laboratory study, 35 male Wistar rats were purchased from the Pasteur Institute of Iran and after one week of familiarization with the new environment, they were randomly divided into five groups: Control (NO), Alzheimer's (AD), Alzheimer's-exercise (ADT), Alzheimer's-resveratrol (ADRSV), and Alzheimer's-exercise-resveratrol (ADTRSV). The supplement groups received 20 mg of RSV (per kilogram of body weight) orally daily during the intervention period. The aerobic exercise program included treadmill running at a speed of 6-18 meters per minute, five days a week for eight weeks.
Results: The results showed that AD induction caused a significant decrease in the expression of MNF1 and MNF2 (p=0.0001). A significant increase in the expression of MNF1 and MNF2 was observed in the ADT, ADRSV, and ADTRSV groups compared to AD (p≤0.05).
Conclusion: Mitochondrial dynamics are disrupted following AD induction in hippocampal tissue, and exercise and resveratrol increase mitochondrial fusion and reduce fission by increasing Mfn1 and Mfn2 levels. However, the combination of exercise and resveratrol did not have a synergistic effect on fission genes.
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