Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Department of exercise physiology, Sh.C., Islamic Azad University, Shiraz, Iran
2 Department of exercise physiology, Marv.C, Islamic Azad University, Marvdasht, Iran
Abstract
Introduction: The present study was done to investigate the effect of aerobic exercise and royal jelly consumption MDA, CAT, and SOD levels in the lung tissue of an animal model with lung cancer.
Methodology: Forty-eight male BALB/C mice, with an average age of eight weeks, were divided into healthy, sham, lung cancer (LC), swimming training (ST), royal jelly 50 (RJ50), royal jelly 100 (RJ100), swimming training + royal jelly 50 (ST.RJ50), and swimming training + royal jelly 100 (ST.RJ100) groups (n=6). Lung cancer induction was performed by injection of 100 mg/kg of benzo[a]pyrene. Swimming training was performed for 12 weeks, 5 days per week. Royal jelly was also injected intraperitoneally at doses of 50 and 100 mg/kg of body weight. 48 hours after the last training session, the amount of MDA, CAT, and SOD in lung tissue was measured and the data were analyzed by one-way ANOVA test.
Results: The MDA value in the LC, RJ50, RJ100, and ST groups was higher than the healthy control and sham groups, and was lower in the ST.RJ100 group than in the other intervention groups (p<0.05). Also, CAT and SOD levels were lower in the LC, RJ50, and ST groups compared to the healthy control group, and higher in the ST.RJ100 group compared to other intervention groups except the ST.RJ50 group (p<0.05).
Conclusions: It seems that the combination of swimming training with high doses of royal jelly is effective in improving oxidative stress in lung cancer mice by increasing antioxidant enzymes.
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