Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
- mojtaba Miri Fakhrababd, 1
- Najmeh Rezaeian 2
- Sadegh Cheragh Birjandi 1
- Ali Yaghoubi 1
- mohsen tavakoli 1
1 bojnourd
2 Department of physical education, Bojnourd branch, Islamic Azad University, Bojnourd, Iran
Abstract
Piezo-1 is known as a mechanoreceptor associated with adipogenesis, adipose tissue inflammation, and insulin resistance. The aim of the present study was to compare the effect of eight weeks of high-intensity resistance, endurance, and interval training on Piezo-1 gene expression and insulin resistance index in obese male rats. Twenty-four male Wistar rats (10 weeks, 200±10.2 g) were randomly divided into four groups after six weeks of high-fat diet, including 1) high-intensity interval training (HIIT), 2) resistance training (RT), 3) endurance training (ET), and 4) control (Co) and participated in eight weeks of training, five sessions per week. Rats were dissected 48 hours after the last training session, and the studied indices were evaluated using an appropriate laboratory method. Data analysis was performed using one-way ANOVA and paired t-test at a significance level of less than 0.05. There was a significant difference between the changes in Piezo-1 gene expression, serum insulin levels, fasting blood glucose, HOMA-IR, and body weight after eight weeks of RT, ET, and HIIT. In addition, body weight in the high-intensity interval training group was significantly reduced at the posttest compared to the pretest. Considering the antidiabetic and antiobesity functions of Piezo-1, it seems that increasing Piezo-1 gene expression in adipose tissue after eight weeks of high-intensity interval training, resistance, and endurance training can help improve insulin resistance.
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