Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Education Nowshahr, Mazandaran
2 Department of exercise physiology, Am.C., Islamic Azad University, Amol, Iran.
Abstract
Objective: Alzheimer is a progressive neurodegenerative disorder that gradually impairs mental abilities through abnormal protein accumulation, as well as inflammatory and oxidative processes.. the present study aimed to investigate the synergistic effects of aerobic exercise and Rhodiola rosea extract on brain-derived neurotrophic factor (BDNF) expression and oxidative stress indices in the brain tissue of mice with Alzheimer..
Methodology: 30 male C57BL/6 mice with an weight of 14 ± 2 g and an age of 12 weeks were randomly assigned to five groups: (1) healthy control, (2) Alzheimer’s, (3) Alzheimer’s + exercise, (4) Alzheimer’s + Rhodiola, and (5) Alzheimer’s + exercise + Rhodiola. The Alzheimer’s model was induced by intrahippocampal injection of Aβ₁₋₄₂. Mice in the training groups performed treadmill running for 30–45 minutes per session, five days per week, at a speed of 10–18 m/min for eight weeks. Rhodiola extract was administered by gavage at a dose of 200 mg/kg on training days. Data were analyzed using one-way ANOVA followed by Tukey test in SPSS.
Results: BDNF gene expression and SOD activity levels in the Alzheimer’s + exercise, Alzheimer’s + Rhodiola, and Alzheimer’s + exercise + Rhodiola groups were significantly higher than those in the Alzheimer’s group (P < 0.001). serum MDA levels were significantly lower in these three intervention groups compared with the Alzheimer’s group (P < 0.001).
Conclusion: the concurrent application of aerobic exercise and Rhodiola rosea extract represents an effective, non-invasive, and low-risk strategy for modulating oxidative stress and promoting neuronal regeneration under neurodegenerative conditions.
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