Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Msc, Department of Sport Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
2 Associate Professor, Department of Sport Sciences, Azarbaijan Shahid Madani University, Tabriz, Iran.
3 Associate Professor of Azarbaijan Shahid Madani University, Tabriz, Iran
Abstract
Objective: Type II diabetes exacerbates neurodegeneration by altering the processing of amyloid beta (Aβ), and aerobic exercise training and antidiabetic herbal supplements such as bitter melon may alter this process. However, direct data on the combined effects of the two, which was investigated in this study, are lacking.
Methodology: Forty middle-aged female volunteers with type II diabetes were randomly assigned into four groups (aerobic exercise and bitter melon, exercise and placebo, bitter melon, and control). Interval aerobic exercise training was conducted for eight weeks (three sessions per week) with a duration of (20 to 60 minutes per session with one minute active rest intervals at 60 to 75% of RHR). Bitter melon fruit powder was consumed at a dose of eight mg/kg in three equal doses per day in a double-blind order. Enzymatic methods, HPLC, ELISA, TUG, six-minute walk test, and digit span as well as picture recall memory tests were used to collect data in two stages, which were analyzed with paired t-tests and one-way analysis of variance at a confidence level of 95%.
In all three groups, body weight, time to up and go, blood glucose, triglycerides and HDL as well as serum A1c, insulin and AB42 decreased, while blood HDL and serum ADAM10, distance covered in the walking test, short-term and medium-term memory function and upper body strength increased (P<0.05 in all circumstances). ...
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