Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
1 Department of physical education, Bojnourd .C., Islamic Azad University, Bojnourd, Iran
2 Department of physical education, Bojnourd branch, Islamic Azad University, Bojnourd, Iran
Abstract
Isthmin 1 (ISM1) is a newly identified insulin-like adipokine that increases glucose uptake by adipocytes and inhibits hepatic lipid synthesis. Purpose of this study was to investigate the effect of eight weeks of aerobic training on adipose tissue levels of isthmin-1 and triglyceride-glucose (TyG) index and lipids profile in male obese diabetic rats.Twenty rats (10-12 weeks old, 276.4±11.20 gr) randomly divided in to two groups of experimental and control (11 ones in each) following induction of obesity and diabetes by high fat diet and injection of Streptozotocin. Rats in experimental group participated in eight weeks of aerobic training of running on treadmill at intensity of 10-26 percentage of maximum velocity, 10-55 minutes per session and five days per week. All rats were dissected after the last training session, and the investigated indicators were evaluated. Eight weeks of aerobic training resulted in significant decreases in levels of TyG index (P=0.018), fast blood sugar (FBS) , triglyceride, cholesterol , low-density lipoprotein (LDL) and weight in addition to significant increases in adipose tissue levels of isthmin-1 (P=0.003) and high-density lipoprotein (HDL) (P=0.039) in experimental group compared to control one. Moreover, FBS (P=0.004) and weight (P=0.036) significantly declined in experimental group in post-test compared to pre-test. Furthermore, there were significant correlations between changes in isthmin-1 levels after aerobic training with changes in FBS , TyG index , triglyceride, cholesterol and HDL . It seems that eight weeks of aerobic training modulates metabolic and lipids profiles through increasing isthmin-1 levels in obese diabetic rats.
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