Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
- Mahsa Jamali 1
- Hashmat ollah Persians 2
- Shahram Sohaily 3
- Mohammad Ali Azarbayjani 4
- Ruhollah Ershadhi 5
1 Azad University
2 Islamic Azad University, Shahr-e-Qods Branch
3 Physiology, Faculty of Physical Education, Shahr-e-Quds Branch, Tehran, Iran
4 Exercise Physiology, Daneshke Physical Education, Tehran, Iran
5 Physical Education, Bushehr Branch, Islamic Azad University, Bushehr, Iran
Abstract
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Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by inflammation and elevated markers such as anti-ds-DNA and ESR. Physical activity can help reduce systemic inflammation. The aim of the present study was to investigate the effect of 12 weeks of dry land walking exercises on inflammatory markers in men with SLE.
In this quasi-experimental study, 14 men aged 20-40 years were randomly divided into two groups: intervention (dry land walking) and control. The exercise program included moderate-intensity walking, 20-50 minutes, three sessions per week, with an intensity of 40-70% of heart rate reserve. Markers of CRP, ESR, ds-DNA, WBC, RBC, Platelet, and Immature Granulocyte were measured before and 48 hours after the intervention.
The Shapiro-Wilk test was used to assess data normality, and due to non-normal data, analyses were performed using non-parametric methods. Non-parametric Analysis of Covariance was used for group comparisons, and the Mann-Whitney U test was used for pairwise comparisons.
The results showed a significant reduction in ESR in the intervention group compared to the control group (p < 0.05). Other variables showed a relative decrease but were not statistically significant. Clinical improvements such as reduced fatigue were also reported. Given the limited sample size, the interpretation of results requires caution.
Conclusion: Dry land walking exercises can be proposed as a safe and feasible intervention to reduce inflammation in SLE patients, but larger studies are needed to confirm the findings.
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