Document Type : Research Paper I Open Access I Released under (CC BY-NC) license
Authors
Department of Physical Education and Sport Sciences, QaS.C., Islamic Azad University, Qaemshahr, Iran
Abstract
Introduction: Since drug treatments have limited effectiveness in Alzheimer's, attention has increased to non-pharmacological approaches, including physical activity and natural compounds such as resveratrol. The aim of the present study was to determine the protective effect of interval training and resveratrol supplementation on hippocampal autophagy indices in Alzheimer's rats with beta-amyloid.
Methods: To conduct the present experimental study, 35 male Wistar rats were divided into five groups: control (CO), Alzheimer (AD), Alzheimer-exercise (ADT), Alzheimer-resveratrol (ADRSV), and Alzheimer-exercise-resveratrol (ADTRSV). The supplement groups received 20 mg RSV (per kg body weight) orally daily during the intervention period. The high-intensity interval training (HIIT) program consisted of 10 repetitions of 30-second runs on a treadmill without incline with a 2.5-minute rest period.
Results: A significant decrease in the rate of changes in PARKIN and PINK1 gene expression was observed in the AD, ADT, and ADRSV groups compared to NO. A significant increase was also observed in the ADT, ADRSV, and ADTRSV groups compared to AD; and ADTRSV compared to the ADT and ADRSV groups. In addition, a significant increase in the rate of changes in FOXO1 and FOXO3 gene expression was observed in the AD, ADT, and ADRSV groups compared to NO. FOXO1 and FOXO3 were significantly decreased in ADTRSV compared to ADT, ADT, and ADRSV groups.
Conclusion: According to the results of the study, the use of a combined intervention of interval training and resveratrol supplementation to improve Alzheimer's disease under the supervision of the researcher is recommended.
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