R Fathi; M Baghersalimi; M Nazemi; A Khosravi
Abstract
Aim: Dipeptidyl-peptidase-4 (DPP-4) has been proposed as a bridge between obesity and insulin resistance (IR). The aim of this study was to investigate the changes in serum levels of DPP-4 and HOMA2-IR after eight weeks of interval and continuous-walking in 9-11 year-old obese girls. Method: thirty two-obese ...
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Aim: Dipeptidyl-peptidase-4 (DPP-4) has been proposed as a bridge between obesity and insulin resistance (IR). The aim of this study was to investigate the changes in serum levels of DPP-4 and HOMA2-IR after eight weeks of interval and continuous-walking in 9-11 year-old obese girls. Method: thirty two-obese girls (age: 9.62±0.75 years and BMI-percentile: 97.38±1.40%) volunteered in this study and were assigned to interval (n=12), continuous (n=11) and control (n=9) groups. The training were performed for 8-weeks, 3-sessions per week (30-min walking in the continuous and interval groups with 60-75%HRmax and 70-85%HRmax, respectively). Interval-walking included 2-min of walking and 1-min of active rest. After 10-hours of fasting, blood sampling was performed before the beginning of training and 72-hours after the last session. The paired t-test was used to examine the within-group changes. Results: Eight weeks of continuous and interval training did not significantly change the levels of DPP-4, insulin, glucose, and HOMA2-IR compared to the control group. Compared to the control group, the interval training resulted in improvement of the body weight, BMI, and BMI percentile (p=0.004, p=0.019, p=0.022), while the BMI only tended to decrease in the continuous training group (p=0.077). Conclusion: It seems that the improvement of the body composition due to the protocol used in this study was not sufficient to make significant changes in the HOMA2-IR and DPP-4 in early-pubertal obese girls.
A Khosravi; R Fathi; M Saghebjoo
Abstract
Aim: Angiopoietin-like proteins that be involved in the regulation of lipid metabolism, can be potentially utilized in therapies for metabolic syndrome. The purpose of this study was to investigate the effect of eight weeks intermittent and continuous exercise training on serum angiopoietin-like protein ...
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Aim: Angiopoietin-like proteins that be involved in the regulation of lipid metabolism, can be potentially utilized in therapies for metabolic syndrome. The purpose of this study was to investigate the effect of eight weeks intermittent and continuous exercise training on serum angiopoietin-like protein 8 levels and lipid profile in 9-11 years old obese girls. Method: Thirty students aged 9 to 11 years old with a percentile of body mass index more than 90% were randomly assigned to control (n = 9), continuous training (n = 11), and intermittent exercise (12). The exercises included eight weeks of continuous and intermittent walking (3 sessions per week). The subjects underwent continuous training in the first four weeks with 60-75% HRmax and in the second four weeks with of 70-75% HRmax, and subjects with intermittent exercises in the first four weeks with intensity of 75-80% HRmax and in the second four weeks with of 80-85% HRmax. Serum levels of ANGPTL8, HDL, LDL, TG, TC and glucose was measured in pre-test and post-test. Results: The results of this study showed that in the intermittent group, ANGPTL8, TC, glucose increased (p< 0.05), and BMI and percentile of body mass index decreased (p<0.05). In the continuous group, the levels of ANGPTL8 and TC increased (p< 0.05) and BMI decreased (p<0.05). Comparison between groups showed that glucose and ANGPTL8 were not significantly different in two groups. Conclusion: The increased of angiopoietin-like protein 8 after eight weeks of continuous and intermittent exercises was independent of the type of exercise. It seems that, one of the main reasons is the increase of glucose and TC, which suggests the therapeutic potential of angiopoietin-like protein 8 in reducing these factors by inhibiting it.
A Khosravi; R Fathi; M Baghersalimi; A Rasouli
Abstract
Aim: Angiopoietin-like protein 8 (ANGPTL8) is a hepatocyte-derived circulating factor that regulates plasma triglycerides levels. The purpose of this study was to investigate the response of serum ANGPTL8 levels to acute exercise in physically active young men..
Method: Eleven healthy, active young ...
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Aim: Angiopoietin-like protein 8 (ANGPTL8) is a hepatocyte-derived circulating factor that regulates plasma triglycerides levels. The purpose of this study was to investigate the response of serum ANGPTL8 levels to acute exercise in physically active young men..
Method: Eleven healthy, active young males (aged 24±3.63 years, BMI 22.98±2 kg/m2) volunteered for this study. Acute exercise protocol comprising 2 series of 6×10 s sprinting cycling with maximal effort and 10 min active rest (cycling with intensity 65%–75% HRmax).Blood samples were obtained at fasting state, pre-exercise (30 min after breakfast ~365 kcal), immediately, 15, 30 and 45 min after exercise for measuring serum variables. The repeated measures of ANOVA and Bonferroni post-hoc test used to evaluate changes of parameters in the different times. The relationship between variables was assessed using the Pearson correlation coefficient.
Results: The results of present study showed that ANGPTL8, glucose, insulin, lactate, TG and LDL-C levels significantly changed in any time courses of this study (p<0.05). At fasting state, 30 min after breakfast (before exercise) and post-exercise, ANGPTL8 levels not correlated with glucose, insulin, lactate, TG, TC, HDL-C and LDL-C. There was no significant relationship between ANGPTL8 and weight, BMI and body fat percentage.
Conclusion: It seems that acute and short-term exercise is make significant changes in serum levels of ANGPTL8. On the other hand no significant relationship between ANGPTL8 and body composition may related to indvisual differences.
