Nasrin Ramzany; Abasali Gaeini; Sirou Choobineh; Mohamadreza Kordi; Mehdi Hedayati
Volume 5, Issue 2 , February 2016, , Pages 89-98
Abstract
Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 ...
Read More
Aim: RBP4 is an adipokin that participates in insulin function and glucose metabolism. The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. Method: Eighteen male 8-week-old wistar rats (233.6±13.1 g) were selected as sample research. Diabetes was induced by using nikotinamid and streptozotocin. Five days after inducing diabetes, fasting blood was measured using blood glucose strips and rats that the level of fasting blood glucose was between 400-126 mg was selected as diabetic. Rats were randomly and According to homogenization of body weight assigned into two groups including control (n=9) and trained (n=9).Rats in the training groups carried out an 8-week exercise program on a motorized treadmill with 10–25 m/min for 15-40 min/day and a 5% slope for 5 days. Serum RBP4 levels was measured with Elisa method and insulin resistance was measured by HOMA-IR index. Results: Induction of diabetes caused a significant increase in body weight (p=0.001) and serum RBP4 (p<0.05). Also exercise caused a significant increase in muscle weight in the training group (p<0.05). Serum RBP4 levels after training significantly decreased in comparison with control groups (p<0.05). Also glucose, insulin and insulin resistance index were significantly decreased in the training group compared with the control group (p<0.05). Conclusion: it seems that 8 weeks aerobic training with 60-80% vo2max can be effective to decrease the serum RBP4 levels and insulin resistance index in type 2 diabetic patients.
Motahareh Hajati Modaraei; Mohammad Reza Kordi; Aabbas Ali Gaeini
Volume 4, Issue 1 , May 2014, , Pages 39-48
Abstract
Aim: The purpose of this study is to compare the effect of high intensity interval training (HIIT) and aerobic training (AT) on PGC-1α gene expression in the soleus muscle of healthy adult male rats. Method: 18 Wistar male rats were divided into three groups: HIIT (n=6), AT (n=6) and the control ...
Read More
Aim: The purpose of this study is to compare the effect of high intensity interval training (HIIT) and aerobic training (AT) on PGC-1α gene expression in the soleus muscle of healthy adult male rats. Method: 18 Wistar male rats were divided into three groups: HIIT (n=6), AT (n=6) and the control group (n=6). After 2 weeks of adaptation, the exercise protocol started and lasted for 8 weeks. The HIIT protocol was a 6 minute warm-up (50%-60% VO2max), 3 frequencies ( 4 minutes on 90%-100% VO2max and 2 minutes on 50%-60% VO2max) and 6 minutes of cooling down on 60-50% of VO2max and AT protocol was a 6 minute warm-up ( 50%-60% VO2max), main body which lasted for 30 minutes (70%-75% VO2max) and 6 minutes of cooling down ( 50%-60% VO2max). 24 hours after the last workout session, muscle samples were extracted and the expression level of the mentioned variable was measured by RT-PCR. Results: The results marked that PGC-1α gene expression was increased significantly (P≤0.05) after 8 weeks of HIIT and AT, and there were no remarkable differences between the types of exercise. Conclusion: Based on these findings, HIIT and AT have almost the same impact on increasing the muscle PGC-1α gene expression in rats’ soleus muscle.
