hamideh montazery taleghani; nader shakeri; khosrow ebrahim; rahman soori; M Gholami
Abstract
Background: A main reason of death in diabetes is cardiovascular diseases, which apoptosis plays a critical role through the progress. As known, body exercises can avoid damaging effects of apoptosis on human heart. This study is investigating the effects of resistance exercises in a period of 8 weeks ...
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Background: A main reason of death in diabetes is cardiovascular diseases, which apoptosis plays a critical role through the progress. As known, body exercises can avoid damaging effects of apoptosis on human heart. This study is investigating the effects of resistance exercises in a period of 8 weeks on cardiomyocyte apoptosis status in streptozotocin induced diabetic rats..Materials and methods:20 male wistar rats with age of 8 weeks and 210-250 g weight randomly allocated into two groups. Diabetes was induced by a single intraperitoneal injection of STZ (50 mg/kg) in diabetic groups. The resistance training carried out a step ladder, load of 30-100 percentage of weight whereas control group remained sedentary. Measuring training adaptations blood and heart tissue samples were taken bout The level of the serum glucose, insulin, insulin resistance index, and gene expression levels Bcl-2,Bax,caspase8 and the ratio of bax/ Bcl-2 were assessed. Results: Implementation of 8 weeks of resistance exercise resulted significant decrease in gene expression levels Bax and the ratio of bax/ Bcl-2 (p=0/000)and a significant increase in Bcl-2(p=0/000) and caspase 8 (p=0/004) compare with control group in diabetic rats.Conclusion: The results show that resistance exercise may be used as a non‐pharmacological strategy to reduce the diabetes‐induced apoptosis in the heart in diabetes disease. Keyword:Type 2 diabetes,apoptosis,resistance exercise, gene expression
M Gholami; E Eftekhari; A Zafari; O Solatzadeh
Abstract
Aim: despite role of aerobic exercise training in controlling type 2 diabetes, effectiveness of different aerobic training intensity’s and their mechanism is unknown. Therefore, the aim of present study was to investigate the effect of eight weeks' low and moderate intensity aerobic training on ...
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Aim: despite role of aerobic exercise training in controlling type 2 diabetes, effectiveness of different aerobic training intensity’s and their mechanism is unknown. Therefore, the aim of present study was to investigate the effect of eight weeks' low and moderate intensity aerobic training on levels of HbA1C, some hematological parameters and percent body fat in men with type 2 diabetes. Method: subjects in present study was consist of 33 obese and overweight men with type 2 diabetes with average age of 43.2 ± 8.03 and BMI 28.63 ± 2.71 that randomly assigned in three groups (11 in each group) including control, low intensity aerobic exercise training and moderate intensity aerobic training. Low intensity aerobic training program were performed with 50 percent of maximum heart rate (MHR) and moderate intensity aerobic training with 70 percent of MHR. Training program continued for eight weeks and three sessions in week for 45-60 minutes in each session. Results: results indicated that HbA1C, glucose and percent body fat significantly (p<0.05) decreased in both training groups. However, lipid profile significantly was improve only in moderate intensity aerobic training group. Moreover, HbA1C decrease and VO2peak increase in moderate intensity group was significantly diffrent to low intensity group. Conclusion: It seems that low intensity aerobic training in comparison to moderate intensity aerobic training are associated with lower adaptations and improvement in type 2 diabetes patient. Keywords: diabetes mellitus, hematologic parameters, endurance training, body fat percent, glycosylated hemoglobin (HbA1C)
