Cardiovascular, respiratory and cardiometabolic functions in exercise
Karim Azali Alamdari; babak Ebadi Shirmard; Hadi Rohani
Abstract
Background and Aim: Many diseases cause skeletal muscle microvascular rarefaction (MR) and the quantitative determination of the effect size (ES) of exercise training on skeletal muscle capillary to fiber ratio (C/F) can be useful in refining exercise prescriptions for susceptible population. The aim ...
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Background and Aim: Many diseases cause skeletal muscle microvascular rarefaction (MR) and the quantitative determination of the effect size (ES) of exercise training on skeletal muscle capillary to fiber ratio (C/F) can be useful in refining exercise prescriptions for susceptible population. The aim of the present study was to determine the average ES of exercise training on skeletal muscle C/f in patients disposed to MR. Materials and Methods: A search for English articles was conducted in Web of Science, Scopus, and PubMed databases without limiting the year of publication until February 2023. Weighted mean difference (WMD) with 95% confidence intervals was calculated using random effect model. Correlation between variables was investigated using fixed effects model meta-regression.Results: A summary ES achieved as WMD=0.21 (95% CI: 0.17 to 0.26) from the results of 308 subjects, included in 22 exercise training interventions (p=0.014, I2=44.16). No correlations were observed in between the changes in C/F and the age of subjects included in each intervention based on action of the moment’s meta-regression model (r=-0.00, p=0.92, z=0.099). Among the exercise duration categories, interventions less than 8 weeks (n=3) had the least ES on C/F (WMD=0.18), while a WMD of 0.22 were determined for both of interventions with 8 weeks (n=7) and more than 8 weeks duration (n=12) categories (z=9.68, p=0.001). Moreover, interventions in HIIT and intensive aerobic exercise training category had greater ES (WMD=0.23) compared to MICT and aerobic exercise training (WMD= 020) interventions (z=9.73, p=0.001). =
Exercise Physiology
Aghil Mahdavi; Roghayeh Pouzesh Jadidi; Karim Azali Alamdari
Abstract
Introduction: The aim of this study was to evaluate the effects of high-intensity interval training (HIIT) and curcumin supplementation on cardiac heat shock proteins level and gene expression level of microRNAs in rats exposed to arsenic.Methods: 32 male Wistar rats were randomly divided into four groups ...
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Introduction: The aim of this study was to evaluate the effects of high-intensity interval training (HIIT) and curcumin supplementation on cardiac heat shock proteins level and gene expression level of microRNAs in rats exposed to arsenic.Methods: 32 male Wistar rats were randomly divided into four groups of Control, Curcumin, Exercise and concomitant(Curcumin+Exercise). Arsenic 5 mg/kg.day and curcumin 15 mg/kg.day, were consumed orally for entire the study period. HIIT were conducted for six weeks (5 d/w, 60 min/session (consisted of 10 intervals of running (4 min) at 85-90% of Vo2max with 2 min recovery at 50-60% of Vo2max). Tissue protein content and gene expression levels was assessed by Western blotting and PCR methods respectively. Results: No between group difference was observed for gene expression levels of miR-21(P>0.05).The cardiac HSP60, HSP20 levels and the gene expression levels of miR-30 was significantly higher in all three intervention groups compared to Control group(P<0.001). Moreover, the cardiac HSP60, HSP20 content was significantly higher in concomitant group compared to both groups of Exercise and Curcumin(P<0.05). Conclusion: Arsenic exposure may likely increase the vulnerability of cardiomyocytes to injury by altering the amount of heat shock proteins content and the expression levels of microRNAs. Both HIIT and curcumin supplementation could be likely effective to reduce the hazards of arsenic within heart, However, the concomitant intervention might be had more beneficial effects. However, more research is still needed to be done due to the lack of similar evidence and no comprehensive measurement of the influential factors.
Karim Azali Alamdari; Y yavari; R Hosseinzadeh; A Rahbar Ghazi
Abstract
Aim: In this study the effects of a single training session of overweight men before and after a meal on serum acetylated ghrelin levels, daily energy intake and the exercise energy expenditure were compared.
Method: In this semi experimental study, 30 overweight men (Mean and SD age of 25.2±3.54 ...
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Aim: In this study the effects of a single training session of overweight men before and after a meal on serum acetylated ghrelin levels, daily energy intake and the exercise energy expenditure were compared.
Method: In this semi experimental study, 30 overweight men (Mean and SD age of 25.2±3.54 years, BMI 27.96±3.64 kg/m2, weight 83.2±5.8 kg) were randomized into three groups (n = 10) including before lunch training, post lunch training and control. Experimental groups performed eight weeks, three sessions/wk of aerobic training sessions, consisted of 25 to 40 min of treadmill running and/or cycling at maximal fat oxidation intensity, either an hour prior to or two hours after a meal. Exercise energy expenditure, daily caloric intake and fasting serum acylated ghrelin levels in response to a single exercise session were measured as data in both pre and post-test occasions.
Results: A single training session either pre or post lunch meal increases serum acylated ghrelin level (P≤ 0/001), exercise energy expenditure (P≤ 0/001) and daily caloric intake (P≤ 0/001); indicating a compensatory energy intake which lowers the expected exercise-induced weight loss.
However, pre meal exercise leads to more remarkable increases in exercise energy cost (P≤ 0/001) concomitant with an elevated fasting serum acylated ghrelin levels (P≤ 0/001).
Conclusion: If appetite suppression is the only goal for exercise, it seems that exercise training should be performed after meals, and if maximizing each session’s energy cost is the case, it is better to practice before meals.
K Azali Alamadari; S Nasiri; Z Mohammadpour
Abstract
Aim: The aim of this study was to investigate the effects of aerobic training on serum Chemerin levels, inflammatory and cardio-metabolic risk factors in factors in midlife males complicated with metabolic syndrome.
Method: twenty six males with local Met criteria (age: 54.69±3.67 yrs., BMI: ...
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Aim: The aim of this study was to investigate the effects of aerobic training on serum Chemerin levels, inflammatory and cardio-metabolic risk factors in factors in midlife males complicated with metabolic syndrome.
Method: twenty six males with local Met criteria (age: 54.69±3.67 yrs., BMI: 31.21±1.23 kg/m2 and Vo2peak: 20.38±4.49 ml/kg.min) were randomly divided into aerobic training (n=14) and control (n=12) groups. Throughout eight weeks of training (3 sessions /week) the training load were increased from 15-20 min at 50-55% of HRpeak (end GXT heart rate) to 35-40 min at 60-65%. Blood samples were collected at baseline and 48 h after the intervention.
Results: Aerobic training induced significant reductions in all (except for HDL and Vo2peak) the investigated variables (P<0.05). At baseline, body weight and age were recognized as the most important predictors of serum Chemerin (P<0.05). Throughout the intervention period, the changes in blood glucose and CRP were the significant predictors of the concomitant changes in serum Chemerin levels (P<0.01), and the changes of Chemerin were the only predictor of the accompanying changes in CRP level (P<0.03). Conclusion: Chemerin reduces synchronously with the beneficial effects on metabolic and inflammatory indices as well as aerobic fitness level to be likely as the results from blood glucose and CRP modifications induced by aerobic training. However; more research remains to be done because of a little available evidence and limitations from this study.
Keywords: Aerobic training, Chemerin, CRP, Metabolic risk factor
K Azali Alamdari K; M Bashiri; R Shokrzadeh Agha Alilou
Abstract
Aim: Nowadays the effect of physical exercise on diabetes control improvement is evident and the both insulin release and function depends on magnesium (Mg) and Mg even improves insulin sensitivity. However; diabetes causes hypomagnesiumemia which in turn worsens glycemic control in a viscous cycle. ...
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Aim: Nowadays the effect of physical exercise on diabetes control improvement is evident and the both insulin release and function depends on magnesium (Mg) and Mg even improves insulin sensitivity. However; diabetes causes hypomagnesiumemia which in turn worsens glycemic control in a viscous cycle. Likewise; little is known about the synchronized effects of exercise training along with Mg supplementation on diabetes control. Therefore; the aim of this study was to investigate the synergistic effects from eight weeks of aerobic training and magnesium supplementation on metabolic control, blood insulin and glycosylated Hb (A1C) and Mg levels in female patients with type II diabetes. Method: This study was done based on an experimental method using a pretest-posttest design. Thirty volunteer midlife type II diabetic females were randomized into training-Mg, training-placebo and control groups. The subjects consumed magnesium oxide or amylose containing pills (250 mg) once daily in a double blind order for eight weeks. The training groups also experienced eight weeks of moderate intensity aerobic training (3 sessions/week running for 60 min in each session at 40 to 60% of THR). Fasting blood samples were taken at two occasions between 8 to 9 am; baseline and after the intervention and the data were analyzed using paired samples t test and one way ANOVA at 95% significance level. Results: 30% of the subjects had hypomagnesiumemia at baseline. Blood Mg was just elevated in the training-Mg group throughout the intervention (P<0.05). However; blood glucose, insulin, A1C, TG, waist circumference and blood pressure were all declined in both the training groups (P<0.05). Additionally, there were greater depressions in blood glucose and insulin levels of the training-Mg group rather than training placebo group (P<0.05). Conclusion: Aerobic training and synchronized Mg supplementation could provide a better diabetes control along with other therapeutic proceedings.
Karim Azali Alamdari; Farhad Gholami
Volume 5, Issue 2 , February 2016, , Pages 109-119
Abstract
Aim: Retinol binding protein-4 (RBP-4) as an adipokine secreted from adipose tissue, plays an important role in insulin resistance and metabolic disorders. Despite the benefits of aerobic training on metabolic disorders, the effect of aerobic training on RBP-4 and its relation with metabolic factors ...
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Aim: Retinol binding protein-4 (RBP-4) as an adipokine secreted from adipose tissue, plays an important role in insulin resistance and metabolic disorders. Despite the benefits of aerobic training on metabolic disorders, the effect of aerobic training on RBP-4 and its relation with metabolic factors in patients with metabolic syndrome is unclear. Therefore, the aim of this study was to investigate the effect of eight weeks aerobic training on serum RBP-4 levels and insulin resistance in women with metabolic syndrome. Methods: In a semi-experimental study, 24 women with metabolic syndrome (age: 52.79±4.91 yrs, BMI: 32.77±2.37 Kg/m2 and VO2peak: 40±2.55 L/min) were randomly assigned into two groups including exercise (n=12) and control (n=12) groups. Aerobic exercise program was performed for 8 weeks, 3 sessions per week with an intensity of 50-60% of peak oxygen consumption for 20-40 minutes. Prior to the experimental period and 48h after last training session, body composition measurements were performed and blood samples were taken to be measured for serum levels of RBP-4, lipid profile, glucose and insulin. Insulin resistance index was also assessed. The data were analyzed using statistical tests of Paired and Independent t-test and Pearson's correlation test at significance level of PResults: The results showed that aerobic training significantly decreased serum RBP-4, glucose, insulin resistance index, body weight, body fat percentage, body mass index (BMI), waist circumference and metabolic syndrome Z score (P<0.05). Moreover, high density lipoprotein HDL - C levels significantly increased following eight weeks aerobic training (P<0.05). Pearson's correlation test revealed that changes in RBP-4 levels was significantly correlated with changes in body fat percentage, triglycerides, insulin and insulin resistance index (P<0.05). Conclusion: Overall, the results of this study indicated that aerobic training can reduce the RBP-4 levels and improve insulin resistance and some metabolic risk factors in women with metabolic syndrome. Insulin resistance improvement is likely to be resulted from decreased RBP-4 levels following aerobic training.
Arsalan Damirchi; Karim Azali Alamdari; Parvin Babaei
Volume 2, Issue 2 , July 2012, , Pages 135-147
Abstract
Abstract
Aim: Brain derived neurotrophic factor (BDNF) is an important factor affecting cognitive function which has recently interested a bulk trend of effort in the health context. In spite of a good body of evidence reported concern to positive association between aerobic fitness, cognitive function ...
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Abstract
Aim: Brain derived neurotrophic factor (BDNF) is an important factor affecting cognitive function which has recently interested a bulk trend of effort in the health context. In spite of a good body of evidence reported concern to positive association between aerobic fitness, cognitive function and serum BDNF, there is no enough information about the effect of aerobic training and also detraining period on memory function and circulatory BDNF in middle aged individuals.
Method: Twenty one middle aged males (age: 58.08±5.99, weight: 75.79±12.13 kg, BMI: 25.78±2.76 kg.m-2) randomized in two groups including aerobic exercise (Ex, n=11) and control (Con, N=10). Ex subjects participated in six weeks of endurance exercise sessions, 3 sessions/week by the intensity of 60-70% of HRR for 25 to 40 min in each min. Midterm and Short term memory tests were conducted and also blood samples were taken in three occasions including pretest, after six weeks of training and after the following six weeks of detraining period. Data were analyzed using independent t test, ANOVA and ANCOVA repeated measures.
Results: Six weeks of aerobic training in Ex group significantly increased basal serum BDNF level, and also short term and midterm memory function (P
